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Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study

INTRODUCTION: Some micronutrients have key roles in immune defence, including mucosal defence mechanisms and immunoglobulin production. Altered micronutrient status has been linked with COVID-19 infection and disease severity. We assessed the associations of selected circulating micronutrients with...

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Autores principales: Equey, Antoine, Berger, Mette M., Gonseth-Nusslé, Semira, Augsburger, Marc, Rezzi, Serge, Hodgson, Andrew C.C., Estoppey, Sandrine, Pantaleo, Giuseppe, Pellaton, Céline, Perrais, Maïwenn, Lenglet, Sébastien, Rousson, Valentin, D'Acremont, Valérie, Bochud, Murielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110932/
https://www.ncbi.nlm.nih.gov/pubmed/37130500
http://dx.doi.org/10.1016/j.clnu.2023.04.007
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author Equey, Antoine
Berger, Mette M.
Gonseth-Nusslé, Semira
Augsburger, Marc
Rezzi, Serge
Hodgson, Andrew C.C.
Estoppey, Sandrine
Pantaleo, Giuseppe
Pellaton, Céline
Perrais, Maïwenn
Lenglet, Sébastien
Rousson, Valentin
D'Acremont, Valérie
Bochud, Murielle
author_facet Equey, Antoine
Berger, Mette M.
Gonseth-Nusslé, Semira
Augsburger, Marc
Rezzi, Serge
Hodgson, Andrew C.C.
Estoppey, Sandrine
Pantaleo, Giuseppe
Pellaton, Céline
Perrais, Maïwenn
Lenglet, Sébastien
Rousson, Valentin
D'Acremont, Valérie
Bochud, Murielle
author_sort Equey, Antoine
collection PubMed
description INTRODUCTION: Some micronutrients have key roles in immune defence, including mucosal defence mechanisms and immunoglobulin production. Altered micronutrient status has been linked with COVID-19 infection and disease severity. We assessed the associations of selected circulating micronutrients with anti-SARS-CoV-2 IgG and IgA seropositivity in the Swiss community using early pandemic data. METHODS: Case-control study comparing the first PCR-confirmed COVID-19 symptomatic cases in the Vaud Canton (May to June 2020, n = 199) and controls (random population sample, n = 447), seronegative for IgG and IgA. The replication analysis included seropositive (n = 134) and seronegative (n = 152) close contacts from confirmed COVID-19 cases. Anti-SARS-CoV-2 IgG and IgA levels against the native trimeric spike protein were measured using the Luminex immunoassay. We measured plasma Zn, Se and Cu concentrations by ICP-MS, and 25-hydroxy-vitamin D(3) (25(OH)D(3)) with LC-MS/MS and explored associations using multiple logistic regression. RESULTS: The 932 participants (54.1% women) were aged 48.6 ± 20.2 years (±SD), BMI 25.0 ± 4.7 kg/m(2) with median C-Reactive Protein 1 mg/l. In logistic regressions, log(2)(Zn) plasma levels were negatively associated with IgG seropositivity (OR [95% CI]: 0.196 [0.0831; 0.465], P < 0.001; replication analyses: 0.294 [0.0893; 0.968], P < 0.05). Results were similar for IgA. We found no association of Cu, Se, and 25(OH)D(3) with anti-SARS-CoV-2 IgG or IgA seropositivity. CONCLUSION: Low plasma Zn levels were associated with higher anti-SARS-CoV-2 IgG and IgA seropositivity in a Swiss population when the initial viral variant was circulating, and no vaccination available. These results suggest that adequate Zn status may play an important role in protecting the general population against SARS-CoV-2 infection. REGISTRY: CORONA IMMUNITAS: ISRCTN18181860.
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spelling pubmed-101109322023-04-18 Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study Equey, Antoine Berger, Mette M. Gonseth-Nusslé, Semira Augsburger, Marc Rezzi, Serge Hodgson, Andrew C.C. Estoppey, Sandrine Pantaleo, Giuseppe Pellaton, Céline Perrais, Maïwenn Lenglet, Sébastien Rousson, Valentin D'Acremont, Valérie Bochud, Murielle Clin Nutr Original Article INTRODUCTION: Some micronutrients have key roles in immune defence, including mucosal defence mechanisms and immunoglobulin production. Altered micronutrient status has been linked with COVID-19 infection and disease severity. We assessed the associations of selected circulating micronutrients with anti-SARS-CoV-2 IgG and IgA seropositivity in the Swiss community using early pandemic data. METHODS: Case-control study comparing the first PCR-confirmed COVID-19 symptomatic cases in the Vaud Canton (May to June 2020, n = 199) and controls (random population sample, n = 447), seronegative for IgG and IgA. The replication analysis included seropositive (n = 134) and seronegative (n = 152) close contacts from confirmed COVID-19 cases. Anti-SARS-CoV-2 IgG and IgA levels against the native trimeric spike protein were measured using the Luminex immunoassay. We measured plasma Zn, Se and Cu concentrations by ICP-MS, and 25-hydroxy-vitamin D(3) (25(OH)D(3)) with LC-MS/MS and explored associations using multiple logistic regression. RESULTS: The 932 participants (54.1% women) were aged 48.6 ± 20.2 years (±SD), BMI 25.0 ± 4.7 kg/m(2) with median C-Reactive Protein 1 mg/l. In logistic regressions, log(2)(Zn) plasma levels were negatively associated with IgG seropositivity (OR [95% CI]: 0.196 [0.0831; 0.465], P < 0.001; replication analyses: 0.294 [0.0893; 0.968], P < 0.05). Results were similar for IgA. We found no association of Cu, Se, and 25(OH)D(3) with anti-SARS-CoV-2 IgG or IgA seropositivity. CONCLUSION: Low plasma Zn levels were associated with higher anti-SARS-CoV-2 IgG and IgA seropositivity in a Swiss population when the initial viral variant was circulating, and no vaccination available. These results suggest that adequate Zn status may play an important role in protecting the general population against SARS-CoV-2 infection. REGISTRY: CORONA IMMUNITAS: ISRCTN18181860. The Author(s). Published by Elsevier Ltd. 2023-06 2023-04-18 /pmc/articles/PMC10110932/ /pubmed/37130500 http://dx.doi.org/10.1016/j.clnu.2023.04.007 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Equey, Antoine
Berger, Mette M.
Gonseth-Nusslé, Semira
Augsburger, Marc
Rezzi, Serge
Hodgson, Andrew C.C.
Estoppey, Sandrine
Pantaleo, Giuseppe
Pellaton, Céline
Perrais, Maïwenn
Lenglet, Sébastien
Rousson, Valentin
D'Acremont, Valérie
Bochud, Murielle
Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study
title Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study
title_full Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study
title_fullStr Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study
title_full_unstemmed Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study
title_short Association of plasma zinc levels with anti-SARS-CoV-2 IgG and IgA seropositivity in the general population: A case–control study
title_sort association of plasma zinc levels with anti-sars-cov-2 igg and iga seropositivity in the general population: a case–control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110932/
https://www.ncbi.nlm.nih.gov/pubmed/37130500
http://dx.doi.org/10.1016/j.clnu.2023.04.007
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