SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor

Via an insufficient coat protein complex I (COPI) retrieval signal, the majority of SARS-CoV-2 spike (S) is resident in host early secretory organelles and a tiny amount is leaked out in cell surface. Only surface-exposed S can be recognized by B cell receptor (BCR) or anti-S therapeutic monoclonal...

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Detalles Bibliográficos
Autores principales: Li, Yiqun, Yang, Mingrui, Nan, Yanan, Wang, Jiaming, Wang, Sanjiao, Cui, Dongxiao, Guo, Jiajian, He, Pengfei, Dai, Wenxin, Zhou, Shuqi, Zhang, Yue, Ma, Wenfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110937/
https://www.ncbi.nlm.nih.gov/pubmed/37360012
http://dx.doi.org/10.1016/j.apsb.2023.04.007

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