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Role of GM-CSF in lung balance and disease
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor originally identified as a stimulus that induces the differentiation of bone marrow progenitor cells into granulocytes and macrophages. GM-CSF is now considered to be a multi-origin and pleiotropic cytokine. G...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111008/ https://www.ncbi.nlm.nih.gov/pubmed/37081870 http://dx.doi.org/10.3389/fimmu.2023.1158859 |
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author | Chen, Yingzi Li, Fan Hua, Mengqing Liang, Meng Song, Chuanwang |
author_facet | Chen, Yingzi Li, Fan Hua, Mengqing Liang, Meng Song, Chuanwang |
author_sort | Chen, Yingzi |
collection | PubMed |
description | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor originally identified as a stimulus that induces the differentiation of bone marrow progenitor cells into granulocytes and macrophages. GM-CSF is now considered to be a multi-origin and pleiotropic cytokine. GM-CSF receptor signals activate JAK2 and induce nuclear signals through the JAK-STAT, MAPK, PI3K, and other pathways. In addition to promoting the metabolism of pulmonary surfactant and the maturation and differentiation of alveolar macrophages, GM-CSF plays a key role in interstitial lung disease, allergic lung disease, alcoholic lung disease, and pulmonary bacterial, fungal, and viral infections. This article reviews the latest knowledge on the relationship between GM-CSF and lung balance and lung disease, and indicates that there is much more to GM-CSF than its name suggests. |
format | Online Article Text |
id | pubmed-10111008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101110082023-04-19 Role of GM-CSF in lung balance and disease Chen, Yingzi Li, Fan Hua, Mengqing Liang, Meng Song, Chuanwang Front Immunol Immunology Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor originally identified as a stimulus that induces the differentiation of bone marrow progenitor cells into granulocytes and macrophages. GM-CSF is now considered to be a multi-origin and pleiotropic cytokine. GM-CSF receptor signals activate JAK2 and induce nuclear signals through the JAK-STAT, MAPK, PI3K, and other pathways. In addition to promoting the metabolism of pulmonary surfactant and the maturation and differentiation of alveolar macrophages, GM-CSF plays a key role in interstitial lung disease, allergic lung disease, alcoholic lung disease, and pulmonary bacterial, fungal, and viral infections. This article reviews the latest knowledge on the relationship between GM-CSF and lung balance and lung disease, and indicates that there is much more to GM-CSF than its name suggests. Frontiers Media S.A. 2023-04-04 /pmc/articles/PMC10111008/ /pubmed/37081870 http://dx.doi.org/10.3389/fimmu.2023.1158859 Text en Copyright © 2023 Chen, Li, Hua, Liang and Song https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Yingzi Li, Fan Hua, Mengqing Liang, Meng Song, Chuanwang Role of GM-CSF in lung balance and disease |
title | Role of GM-CSF in lung balance and disease |
title_full | Role of GM-CSF in lung balance and disease |
title_fullStr | Role of GM-CSF in lung balance and disease |
title_full_unstemmed | Role of GM-CSF in lung balance and disease |
title_short | Role of GM-CSF in lung balance and disease |
title_sort | role of gm-csf in lung balance and disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111008/ https://www.ncbi.nlm.nih.gov/pubmed/37081870 http://dx.doi.org/10.3389/fimmu.2023.1158859 |
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