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Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge

BACKGROUND: Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear. METHODS: We conducted a prospective follow-up study to evaluate the long-term symptoms and clinical i...

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Autores principales: Zhang, Dongmei, Zhou, Yaya, Ma, Yanling, Chen, Ping, Tang, Jian, Yang, Bohan, Li, Hui, Liang, Mengyuan, Xue, YuE, Liu, Yao, Zhang, Jianchu, Wang, Xiaorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111044/
https://www.ncbi.nlm.nih.gov/pubmed/37069814
http://dx.doi.org/10.3346/jkms.2023.38.e120
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author Zhang, Dongmei
Zhou, Yaya
Ma, Yanling
Chen, Ping
Tang, Jian
Yang, Bohan
Li, Hui
Liang, Mengyuan
Xue, YuE
Liu, Yao
Zhang, Jianchu
Wang, Xiaorong
author_facet Zhang, Dongmei
Zhou, Yaya
Ma, Yanling
Chen, Ping
Tang, Jian
Yang, Bohan
Li, Hui
Liang, Mengyuan
Xue, YuE
Liu, Yao
Zhang, Jianchu
Wang, Xiaorong
author_sort Zhang, Dongmei
collection PubMed
description BACKGROUND: Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear. METHODS: We conducted a prospective follow-up study to evaluate the long-term symptoms and clinical indices of RPs at one-year after discharge from Union Hospital, Wuhan, China between December 2020 to May 2021. We also performed the 16S rRNA sequencing of stool samples from RPs and healthy controls (HCs) and analyzed the correlation between the gut microbiota and long COVID-19. RESULTS: In total, 187 RPs were enrolled, among them, 84 (44.9%) RPs reported long COVID-19 symptoms at one-year after discharge. The most common long-term symptoms were cardiopulmonary symptoms, including chest tightness after activity (39/187, 20.9%), palpitations on exercise (27/187, 14.4%), sputum (21/187, 11.2%), cough (15/187, 8.0%) and chest pain (13/187, 7.0%), followed by systemic symptoms including fatigue (34/187, 18.2%) and myalgia (20/187, 10.7%), and digestive symptoms including constipation (14/187, 7.5%), anorexia (13/187, 7.0%), and diarrhea (8/187, 4.3%). Sixty-six (35.9%) RPs presented either anxiety or depression (42/187 [22.8%] and 53/187 [28.8%] respectively), and the proportion of anxiety or depression in the long symptomatic group was significantly higher than that in the asymptomatic group (41/187 [50.6%] vs. 25/187 [24.3%]). Compared with the asymptomatic group, scores of all nine 36-Item Short Form General Health Survey domains were lower in the symptomatic group (all P < 0.05). One hundred thirty RPs and 32 HCs (non-severe acute respiratory syndrome coronavirus 2 infected subjects) performed fecal sample sequencing. Compared with HCs, symptomatic RPs had obvious gut microbiota dysbiosis including significantly reduced bacterial diversities and lower relative abundance of short-chain fatty acids (SCFAs)-producing salutary symbionts such as Eubacterium_hallii_group, Subdoligranulum, Ruminococcus, Dorea, Coprococcus, and Eubacterium_ventriosum_group. Meanwhile, the relative abundance of Eubacterium_hallii_group, Subdoligranulum, and Ruminococcus showed decreasing tendencies between HCs, the asymptomatic group, and the symptomatic group. CONCLUSION: This study demonstrated the presence of long COVID-19 which correlates with gut microbiota dysbiosis in RPs at one-year after discharge, indicating gut microbiota may play an important role in long COVID-19.
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spelling pubmed-101110442023-04-19 Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge Zhang, Dongmei Zhou, Yaya Ma, Yanling Chen, Ping Tang, Jian Yang, Bohan Li, Hui Liang, Mengyuan Xue, YuE Liu, Yao Zhang, Jianchu Wang, Xiaorong J Korean Med Sci Original Article BACKGROUND: Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is gradually recognized by more people. However, how long it will last and the underlining mechanism remains unclear. METHODS: We conducted a prospective follow-up study to evaluate the long-term symptoms and clinical indices of RPs at one-year after discharge from Union Hospital, Wuhan, China between December 2020 to May 2021. We also performed the 16S rRNA sequencing of stool samples from RPs and healthy controls (HCs) and analyzed the correlation between the gut microbiota and long COVID-19. RESULTS: In total, 187 RPs were enrolled, among them, 84 (44.9%) RPs reported long COVID-19 symptoms at one-year after discharge. The most common long-term symptoms were cardiopulmonary symptoms, including chest tightness after activity (39/187, 20.9%), palpitations on exercise (27/187, 14.4%), sputum (21/187, 11.2%), cough (15/187, 8.0%) and chest pain (13/187, 7.0%), followed by systemic symptoms including fatigue (34/187, 18.2%) and myalgia (20/187, 10.7%), and digestive symptoms including constipation (14/187, 7.5%), anorexia (13/187, 7.0%), and diarrhea (8/187, 4.3%). Sixty-six (35.9%) RPs presented either anxiety or depression (42/187 [22.8%] and 53/187 [28.8%] respectively), and the proportion of anxiety or depression in the long symptomatic group was significantly higher than that in the asymptomatic group (41/187 [50.6%] vs. 25/187 [24.3%]). Compared with the asymptomatic group, scores of all nine 36-Item Short Form General Health Survey domains were lower in the symptomatic group (all P < 0.05). One hundred thirty RPs and 32 HCs (non-severe acute respiratory syndrome coronavirus 2 infected subjects) performed fecal sample sequencing. Compared with HCs, symptomatic RPs had obvious gut microbiota dysbiosis including significantly reduced bacterial diversities and lower relative abundance of short-chain fatty acids (SCFAs)-producing salutary symbionts such as Eubacterium_hallii_group, Subdoligranulum, Ruminococcus, Dorea, Coprococcus, and Eubacterium_ventriosum_group. Meanwhile, the relative abundance of Eubacterium_hallii_group, Subdoligranulum, and Ruminococcus showed decreasing tendencies between HCs, the asymptomatic group, and the symptomatic group. CONCLUSION: This study demonstrated the presence of long COVID-19 which correlates with gut microbiota dysbiosis in RPs at one-year after discharge, indicating gut microbiota may play an important role in long COVID-19. The Korean Academy of Medical Sciences 2023-04-05 /pmc/articles/PMC10111044/ /pubmed/37069814 http://dx.doi.org/10.3346/jkms.2023.38.e120 Text en © 2023 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zhang, Dongmei
Zhou, Yaya
Ma, Yanling
Chen, Ping
Tang, Jian
Yang, Bohan
Li, Hui
Liang, Mengyuan
Xue, YuE
Liu, Yao
Zhang, Jianchu
Wang, Xiaorong
Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge
title Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge
title_full Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge
title_fullStr Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge
title_full_unstemmed Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge
title_short Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge
title_sort gut microbiota dysbiosis correlates with long covid-19 at one-year after discharge
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111044/
https://www.ncbi.nlm.nih.gov/pubmed/37069814
http://dx.doi.org/10.3346/jkms.2023.38.e120
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