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Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia

As effective therapies for relapse and refractory B-cell acute lymphoblastic leukemia (B-ALL) remain problematic, novel therapeutic strategies are needed. Artemis is a key endonuclease in V(D)J recombination and nonhomologous end joining (NHEJ) of DNA double-strand break (DSB) repair. Inhibition of...

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Detalles Bibliográficos
Autores principales:	Ogana, Heather A., Hurwitz, Samantha, Hsieh, Chih-Lin, Geng, Huimin, Müschen, Markus, Bhojwani, Deepa, Wolf, Mark A., Larocque, James, Lieber, Michael R., Kim, Yong Mi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111164/ https://www.ncbi.nlm.nih.gov/pubmed/37082620 http://dx.doi.org/10.3389/fcell.2023.1134121

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