Cargando…

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

OBJECTIVE: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring. METHODS: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random samplin...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Yingying, Chen, Zhiwei, Qian, Qinfang, Wang, Yanxia, Xiu, Xiaoyan, Ou, Ping, Fang, Jiaoning, Li, Guobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111374/
https://www.ncbi.nlm.nih.gov/pubmed/37082119
http://dx.doi.org/10.3389/fendo.2023.1114250
_version_ 1785027437468319744
author Lin, Yingying
Chen, Zhiwei
Qian, Qinfang
Wang, Yanxia
Xiu, Xiaoyan
Ou, Ping
Fang, Jiaoning
Li, Guobo
author_facet Lin, Yingying
Chen, Zhiwei
Qian, Qinfang
Wang, Yanxia
Xiu, Xiaoyan
Ou, Ping
Fang, Jiaoning
Li, Guobo
author_sort Lin, Yingying
collection PubMed
description OBJECTIVE: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring. METHODS: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random sampling method from May to September 2019. They were divided into four groups based on paternal BMI. Univariate and multivariate logistic regression were used to explore the relationship between paternal BMI groups, maternal-neonatal outcomes, and long-term prognosis in offspring. Further subgroup analysis was conducted to examine the stability of the risk. RESULTS: The incidences of hypertensive disorder complicating pregnancy (HDCP), cesarean delivery, gestational weight gain (GWG) over guideline, and macrosomia were significantly higher in the paternal overweight and obesity group. Importantly, this study demonstrated that the incidence of asthma, hand-foot-and-mouth disease (HFMD), anemia, dental caries, and obesity of adolescents in paternal obesity increased. Furthermore, logistic regression and subgroup analysis confirm paternal obesity is a risk factor for HDCP, cesarean delivery, and macrosomia. It caused poor long-term prognosis in adolescents, including asthma, dental caries, and HFMD. CONCLUSIONS: Paternal obesity is a risk factor for adverse maternal-neonatal outcomes and poor long-term prognosis in adolescents. In addition to focusing on maternal weight, expectant fathers should pay more attention to weight management since BMI is a modifiable risk factor. Preventing paternal obesity can lead to better maternal and child outcomes. It would provide new opportunities for chronic diseases.
format Online
Article
Text
id pubmed-10111374
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-101113742023-04-19 Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents Lin, Yingying Chen, Zhiwei Qian, Qinfang Wang, Yanxia Xiu, Xiaoyan Ou, Ping Fang, Jiaoning Li, Guobo Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring. METHODS: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random sampling method from May to September 2019. They were divided into four groups based on paternal BMI. Univariate and multivariate logistic regression were used to explore the relationship between paternal BMI groups, maternal-neonatal outcomes, and long-term prognosis in offspring. Further subgroup analysis was conducted to examine the stability of the risk. RESULTS: The incidences of hypertensive disorder complicating pregnancy (HDCP), cesarean delivery, gestational weight gain (GWG) over guideline, and macrosomia were significantly higher in the paternal overweight and obesity group. Importantly, this study demonstrated that the incidence of asthma, hand-foot-and-mouth disease (HFMD), anemia, dental caries, and obesity of adolescents in paternal obesity increased. Furthermore, logistic regression and subgroup analysis confirm paternal obesity is a risk factor for HDCP, cesarean delivery, and macrosomia. It caused poor long-term prognosis in adolescents, including asthma, dental caries, and HFMD. CONCLUSIONS: Paternal obesity is a risk factor for adverse maternal-neonatal outcomes and poor long-term prognosis in adolescents. In addition to focusing on maternal weight, expectant fathers should pay more attention to weight management since BMI is a modifiable risk factor. Preventing paternal obesity can lead to better maternal and child outcomes. It would provide new opportunities for chronic diseases. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10111374/ /pubmed/37082119 http://dx.doi.org/10.3389/fendo.2023.1114250 Text en Copyright © 2023 Lin, Chen, Qian, Wang, Xiu, Ou, Fang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lin, Yingying
Chen, Zhiwei
Qian, Qinfang
Wang, Yanxia
Xiu, Xiaoyan
Ou, Ping
Fang, Jiaoning
Li, Guobo
Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
title Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
title_full Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
title_fullStr Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
title_full_unstemmed Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
title_short Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
title_sort effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111374/
https://www.ncbi.nlm.nih.gov/pubmed/37082119
http://dx.doi.org/10.3389/fendo.2023.1114250
work_keys_str_mv AT linyingying effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT chenzhiwei effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT qianqinfang effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT wangyanxia effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT xiuxiaoyan effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT ouping effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT fangjiaoning effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents
AT liguobo effectsofpaternalobesityonmaternalneonataloutcomesandlongtermprognosisinadolescents