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Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents
OBJECTIVE: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring. METHODS: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random samplin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111374/ https://www.ncbi.nlm.nih.gov/pubmed/37082119 http://dx.doi.org/10.3389/fendo.2023.1114250 |
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author | Lin, Yingying Chen, Zhiwei Qian, Qinfang Wang, Yanxia Xiu, Xiaoyan Ou, Ping Fang, Jiaoning Li, Guobo |
author_facet | Lin, Yingying Chen, Zhiwei Qian, Qinfang Wang, Yanxia Xiu, Xiaoyan Ou, Ping Fang, Jiaoning Li, Guobo |
author_sort | Lin, Yingying |
collection | PubMed |
description | OBJECTIVE: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring. METHODS: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random sampling method from May to September 2019. They were divided into four groups based on paternal BMI. Univariate and multivariate logistic regression were used to explore the relationship between paternal BMI groups, maternal-neonatal outcomes, and long-term prognosis in offspring. Further subgroup analysis was conducted to examine the stability of the risk. RESULTS: The incidences of hypertensive disorder complicating pregnancy (HDCP), cesarean delivery, gestational weight gain (GWG) over guideline, and macrosomia were significantly higher in the paternal overweight and obesity group. Importantly, this study demonstrated that the incidence of asthma, hand-foot-and-mouth disease (HFMD), anemia, dental caries, and obesity of adolescents in paternal obesity increased. Furthermore, logistic regression and subgroup analysis confirm paternal obesity is a risk factor for HDCP, cesarean delivery, and macrosomia. It caused poor long-term prognosis in adolescents, including asthma, dental caries, and HFMD. CONCLUSIONS: Paternal obesity is a risk factor for adverse maternal-neonatal outcomes and poor long-term prognosis in adolescents. In addition to focusing on maternal weight, expectant fathers should pay more attention to weight management since BMI is a modifiable risk factor. Preventing paternal obesity can lead to better maternal and child outcomes. It would provide new opportunities for chronic diseases. |
format | Online Article Text |
id | pubmed-10111374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101113742023-04-19 Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents Lin, Yingying Chen, Zhiwei Qian, Qinfang Wang, Yanxia Xiu, Xiaoyan Ou, Ping Fang, Jiaoning Li, Guobo Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: This study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring. METHODS: This study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random sampling method from May to September 2019. They were divided into four groups based on paternal BMI. Univariate and multivariate logistic regression were used to explore the relationship between paternal BMI groups, maternal-neonatal outcomes, and long-term prognosis in offspring. Further subgroup analysis was conducted to examine the stability of the risk. RESULTS: The incidences of hypertensive disorder complicating pregnancy (HDCP), cesarean delivery, gestational weight gain (GWG) over guideline, and macrosomia were significantly higher in the paternal overweight and obesity group. Importantly, this study demonstrated that the incidence of asthma, hand-foot-and-mouth disease (HFMD), anemia, dental caries, and obesity of adolescents in paternal obesity increased. Furthermore, logistic regression and subgroup analysis confirm paternal obesity is a risk factor for HDCP, cesarean delivery, and macrosomia. It caused poor long-term prognosis in adolescents, including asthma, dental caries, and HFMD. CONCLUSIONS: Paternal obesity is a risk factor for adverse maternal-neonatal outcomes and poor long-term prognosis in adolescents. In addition to focusing on maternal weight, expectant fathers should pay more attention to weight management since BMI is a modifiable risk factor. Preventing paternal obesity can lead to better maternal and child outcomes. It would provide new opportunities for chronic diseases. Frontiers Media S.A. 2023-03-30 /pmc/articles/PMC10111374/ /pubmed/37082119 http://dx.doi.org/10.3389/fendo.2023.1114250 Text en Copyright © 2023 Lin, Chen, Qian, Wang, Xiu, Ou, Fang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Lin, Yingying Chen, Zhiwei Qian, Qinfang Wang, Yanxia Xiu, Xiaoyan Ou, Ping Fang, Jiaoning Li, Guobo Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
title | Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
title_full | Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
title_fullStr | Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
title_full_unstemmed | Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
title_short | Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
title_sort | effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111374/ https://www.ncbi.nlm.nih.gov/pubmed/37082119 http://dx.doi.org/10.3389/fendo.2023.1114250 |
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