Cargando…

Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy

BACKGROUND: Breastfeeding is associated with improved cardiometabolic profiles decades after pregnancy. Whether this association exists for women who experience hypertensive disorders of pregnancy (HDP) is unknown. The authors examined whether breastfeeding duration or exclusivity are associated wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Magnus, Maria C., Wallace, McKenzie K., Demirci, Jill R., Catov, Janet M., Schmella, Mandy J., Fraser, Abigail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111449/
https://www.ncbi.nlm.nih.gov/pubmed/36847057
http://dx.doi.org/10.1161/JAHA.122.026696
_version_ 1785027455408406528
author Magnus, Maria C.
Wallace, McKenzie K.
Demirci, Jill R.
Catov, Janet M.
Schmella, Mandy J.
Fraser, Abigail
author_facet Magnus, Maria C.
Wallace, McKenzie K.
Demirci, Jill R.
Catov, Janet M.
Schmella, Mandy J.
Fraser, Abigail
author_sort Magnus, Maria C.
collection PubMed
description BACKGROUND: Breastfeeding is associated with improved cardiometabolic profiles decades after pregnancy. Whether this association exists for women who experience hypertensive disorders of pregnancy (HDP) is unknown. The authors examined whether breastfeeding duration or exclusivity are associated with long‐term cardiometabolic health, and whether this relationship differs by HDP status. METHODS AND RESULTS: Participants (N=3598) were from the UK ALSPAC (Avon Longitudinal Study of Parents and Children) cohort. HDP status was assessed by medical record review. Breastfeeding behaviors were assessed by contemporaneous questionnaires. Breastfeeding duration was categorized as never, <1, 1 to <3, 3 to <6, 6 to <9, and 9+ months. Breastfeeding exclusivity was categorized as never, <1, 1 to <3, and 3 to 6 months. Measures of cardiometabolic health (body mass index, waist circumference, C‐reactive protein, insulin, proinsulin, glucose, lipids, blood pressure, mean arterial pressure, carotid intima‐media thickness, and arterial distensibility) were measured 18 years after pregnancy. Analyses were conducted using linear regression adjusting for relevant covariates. Breastfeeding was associated with improved cardiometabolic health (lower body mass index, waist circumference, C‐reactive protein, triglycerides, insulin, and proinsulin) in all women, but not for every breastfeeding duration. Interaction tests revealed additional benefits in women with a history of HDP, with the strongest benefit observed in the 6‐ to 9‐month breastfeeding category (diastolic blood pressure, −4.87 mm Hg [95% CI, −7.86 to −1.88], mean arterial pressure −4.61 [95% CI, −7.45 to −1.77], and low‐density lipoprotein cholesterol, −0.40 mmol/L [95% CI, −0.62 to −0.17 mmol/L]). Differences in C‐reactive protein and low‐density lipoprotein “survived” Bonferroni correction (P<0.001). Similar results were observed in the exclusive breastfeeding analyses. CONCLUSIONS: Breastfeeding may be a mechanism to reduce the cardiovascular disease sequela associated with HDP; however, there is a need to establish whether associations reflect a causal effect.
format Online
Article
Text
id pubmed-10111449
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-101114492023-04-19 Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy Magnus, Maria C. Wallace, McKenzie K. Demirci, Jill R. Catov, Janet M. Schmella, Mandy J. Fraser, Abigail J Am Heart Assoc JAHA Spotlight: Go Red for Women BACKGROUND: Breastfeeding is associated with improved cardiometabolic profiles decades after pregnancy. Whether this association exists for women who experience hypertensive disorders of pregnancy (HDP) is unknown. The authors examined whether breastfeeding duration or exclusivity are associated with long‐term cardiometabolic health, and whether this relationship differs by HDP status. METHODS AND RESULTS: Participants (N=3598) were from the UK ALSPAC (Avon Longitudinal Study of Parents and Children) cohort. HDP status was assessed by medical record review. Breastfeeding behaviors were assessed by contemporaneous questionnaires. Breastfeeding duration was categorized as never, <1, 1 to <3, 3 to <6, 6 to <9, and 9+ months. Breastfeeding exclusivity was categorized as never, <1, 1 to <3, and 3 to 6 months. Measures of cardiometabolic health (body mass index, waist circumference, C‐reactive protein, insulin, proinsulin, glucose, lipids, blood pressure, mean arterial pressure, carotid intima‐media thickness, and arterial distensibility) were measured 18 years after pregnancy. Analyses were conducted using linear regression adjusting for relevant covariates. Breastfeeding was associated with improved cardiometabolic health (lower body mass index, waist circumference, C‐reactive protein, triglycerides, insulin, and proinsulin) in all women, but not for every breastfeeding duration. Interaction tests revealed additional benefits in women with a history of HDP, with the strongest benefit observed in the 6‐ to 9‐month breastfeeding category (diastolic blood pressure, −4.87 mm Hg [95% CI, −7.86 to −1.88], mean arterial pressure −4.61 [95% CI, −7.45 to −1.77], and low‐density lipoprotein cholesterol, −0.40 mmol/L [95% CI, −0.62 to −0.17 mmol/L]). Differences in C‐reactive protein and low‐density lipoprotein “survived” Bonferroni correction (P<0.001). Similar results were observed in the exclusive breastfeeding analyses. CONCLUSIONS: Breastfeeding may be a mechanism to reduce the cardiovascular disease sequela associated with HDP; however, there is a need to establish whether associations reflect a causal effect. John Wiley and Sons Inc. 2023-02-27 /pmc/articles/PMC10111449/ /pubmed/36847057 http://dx.doi.org/10.1161/JAHA.122.026696 Text en © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle JAHA Spotlight: Go Red for Women
Magnus, Maria C.
Wallace, McKenzie K.
Demirci, Jill R.
Catov, Janet M.
Schmella, Mandy J.
Fraser, Abigail
Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy
title Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy
title_full Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy
title_fullStr Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy
title_full_unstemmed Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy
title_short Breastfeeding and Later‐Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy
title_sort breastfeeding and later‐life cardiometabolic health in women with and without hypertensive disorders of pregnancy
topic JAHA Spotlight: Go Red for Women
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111449/
https://www.ncbi.nlm.nih.gov/pubmed/36847057
http://dx.doi.org/10.1161/JAHA.122.026696
work_keys_str_mv AT magnusmariac breastfeedingandlaterlifecardiometabolichealthinwomenwithandwithouthypertensivedisordersofpregnancy
AT wallacemckenziek breastfeedingandlaterlifecardiometabolichealthinwomenwithandwithouthypertensivedisordersofpregnancy
AT demircijillr breastfeedingandlaterlifecardiometabolichealthinwomenwithandwithouthypertensivedisordersofpregnancy
AT catovjanetm breastfeedingandlaterlifecardiometabolichealthinwomenwithandwithouthypertensivedisordersofpregnancy
AT schmellamandyj breastfeedingandlaterlifecardiometabolichealthinwomenwithandwithouthypertensivedisordersofpregnancy
AT fraserabigail breastfeedingandlaterlifecardiometabolichealthinwomenwithandwithouthypertensivedisordersofpregnancy