Cargando…
Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation
BACKGROUND: Limited evidence is available on sex differences about the association between hypertension and incident atrial fibrillation (AF). METHODS AND RESULTS: We used a nationwide health checkup and claims database to analyze 3 383 738 adults (median age, 43 (36–51) years, 57.4% men). We invest...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111461/ https://www.ncbi.nlm.nih.gov/pubmed/36802850 http://dx.doi.org/10.1161/JAHA.122.026240 |
_version_ | 1785027458640117760 |
---|---|
author | Kanazawa, Satoshi Kaneko, Hidehiro Yano, Yuichiro Suzuki, Yuta Okada, Akira Matsuoka, Satoshi Fujiu, Katsuhito Michihata, Nobuaki Jo, Taisuke Takeda, Norifumi Morita, Hiroyuki Node, Koichi Yasunaga, Hideo Komuro, Issei |
author_facet | Kanazawa, Satoshi Kaneko, Hidehiro Yano, Yuichiro Suzuki, Yuta Okada, Akira Matsuoka, Satoshi Fujiu, Katsuhito Michihata, Nobuaki Jo, Taisuke Takeda, Norifumi Morita, Hiroyuki Node, Koichi Yasunaga, Hideo Komuro, Issei |
author_sort | Kanazawa, Satoshi |
collection | PubMed |
description | BACKGROUND: Limited evidence is available on sex differences about the association between hypertension and incident atrial fibrillation (AF). METHODS AND RESULTS: We used a nationwide health checkup and claims database to analyze 3 383 738 adults (median age, 43 (36–51) years, 57.4% men). We investigated the relationship between hypertension and incident AF in men and women using a Cox regression model. We used restricted cubic spline functions to identify the association of blood pressure (BP) as a continuous parameter with incident AF. We categorized the men and women into 4 groups according to the 2017 American College of Cardiology/American Heart Association BP guidelines. During a mean follow‐up of 1199±950 days, 13 263 AF diagnoses were recorded. The incidence (95% CI) of AF was 15.8 (15.5–16.1) per 10 000 person‐years in men and 6.1 (5.9–6.3) per 10 000 person‐years in women. Compared with normal BP, elevated BP, stage 1 hypertension, and stage 2 hypertension were associated with an increased risk AF in both men and women. However, the hazard ratios were greater in women than in men, and the P value for interactions in the multivariable model was 0.0076. The models using restricted cubic spline showed that the risk of AF associated with elevated systolic BP increased steeply above an approximate threshold of systolic BP of 130 mm Hg in men and 100 mm Hg in women. Although our primary findings were consistent across subgroup analyses, this association was most significant in younger individuals. CONCLUSIONS: Although the incidence of AF was higher in men, the association between hypertension and incident AF was more pronounced in women than in men, suggesting a potential sex difference in the relationship between hypertension and incident AF. |
format | Online Article Text |
id | pubmed-10111461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101114612023-04-19 Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation Kanazawa, Satoshi Kaneko, Hidehiro Yano, Yuichiro Suzuki, Yuta Okada, Akira Matsuoka, Satoshi Fujiu, Katsuhito Michihata, Nobuaki Jo, Taisuke Takeda, Norifumi Morita, Hiroyuki Node, Koichi Yasunaga, Hideo Komuro, Issei J Am Heart Assoc Original Research BACKGROUND: Limited evidence is available on sex differences about the association between hypertension and incident atrial fibrillation (AF). METHODS AND RESULTS: We used a nationwide health checkup and claims database to analyze 3 383 738 adults (median age, 43 (36–51) years, 57.4% men). We investigated the relationship between hypertension and incident AF in men and women using a Cox regression model. We used restricted cubic spline functions to identify the association of blood pressure (BP) as a continuous parameter with incident AF. We categorized the men and women into 4 groups according to the 2017 American College of Cardiology/American Heart Association BP guidelines. During a mean follow‐up of 1199±950 days, 13 263 AF diagnoses were recorded. The incidence (95% CI) of AF was 15.8 (15.5–16.1) per 10 000 person‐years in men and 6.1 (5.9–6.3) per 10 000 person‐years in women. Compared with normal BP, elevated BP, stage 1 hypertension, and stage 2 hypertension were associated with an increased risk AF in both men and women. However, the hazard ratios were greater in women than in men, and the P value for interactions in the multivariable model was 0.0076. The models using restricted cubic spline showed that the risk of AF associated with elevated systolic BP increased steeply above an approximate threshold of systolic BP of 130 mm Hg in men and 100 mm Hg in women. Although our primary findings were consistent across subgroup analyses, this association was most significant in younger individuals. CONCLUSIONS: Although the incidence of AF was higher in men, the association between hypertension and incident AF was more pronounced in women than in men, suggesting a potential sex difference in the relationship between hypertension and incident AF. John Wiley and Sons Inc. 2023-02-21 /pmc/articles/PMC10111461/ /pubmed/36802850 http://dx.doi.org/10.1161/JAHA.122.026240 Text en © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Kanazawa, Satoshi Kaneko, Hidehiro Yano, Yuichiro Suzuki, Yuta Okada, Akira Matsuoka, Satoshi Fujiu, Katsuhito Michihata, Nobuaki Jo, Taisuke Takeda, Norifumi Morita, Hiroyuki Node, Koichi Yasunaga, Hideo Komuro, Issei Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation |
title | Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation |
title_full | Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation |
title_fullStr | Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation |
title_full_unstemmed | Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation |
title_short | Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation |
title_sort | sex differences in the association between hypertension and incident atrial fibrillation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111461/ https://www.ncbi.nlm.nih.gov/pubmed/36802850 http://dx.doi.org/10.1161/JAHA.122.026240 |
work_keys_str_mv | AT kanazawasatoshi sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT kanekohidehiro sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT yanoyuichiro sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT suzukiyuta sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT okadaakira sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT matsuokasatoshi sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT fujiukatsuhito sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT michihatanobuaki sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT jotaisuke sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT takedanorifumi sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT moritahiroyuki sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT nodekoichi sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT yasunagahideo sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation AT komuroissei sexdifferencesintheassociationbetweenhypertensionandincidentatrialfibrillation |