Collagen‐Specific HSP47 (+) Myofibroblasts and CD163 (+) Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

BACKGROUND: Cardiac fibrosis complicates SARS‐CoV‐2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress‐inducible chaperone protein that regulates biosynthesis and secretion of procollagen in he...

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Detalles Bibliográficos
Autores principales: Puzyrenko, Andrii, Jacobs, Elizabeth R., Padilla, Nathan, Devine, Adam, Aljadah, Michael, Gantner, Benjamin N., Pan, Amy Y., Lai, Shuping, Dai, Qiang, Rubenstein, Jason C., North, Paula E., Simpson, Pippa M., Willoughby, Rodney E., O'Meara, Caitlin C., Flinn, Michael A., Lough, John W., Ibrahim, El‐Sayed H., Zheng, Ze, Sun, Yunguang, Felix, Juan, Hunt, Bryan C., Ross, Gracious, Rui, Hallgeir, Benjamin, Ivor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111490/
https://www.ncbi.nlm.nih.gov/pubmed/36789856
http://dx.doi.org/10.1161/JAHA.122.027990

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