Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis

Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic...

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Autores principales: Ueberham, Laura, Hagendorff, Andreas, Klingel, Karin, Paetsch, Ingo, Jahnke, Cosima, Kluge, Theresa, Ebbinghaus, Hans, Hindricks, Gerhard, Laufs, Ulrich, Dinov, Borislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Mini‐review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111513/
https://www.ncbi.nlm.nih.gov/pubmed/36892055
http://dx.doi.org/10.1161/JAHA.122.027971
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author Ueberham, Laura
Hagendorff, Andreas
Klingel, Karin
Paetsch, Ingo
Jahnke, Cosima
Kluge, Theresa
Ebbinghaus, Hans
Hindricks, Gerhard
Laufs, Ulrich
Dinov, Borislav
author_facet Ueberham, Laura
Hagendorff, Andreas
Klingel, Karin
Paetsch, Ingo
Jahnke, Cosima
Kluge, Theresa
Ebbinghaus, Hans
Hindricks, Gerhard
Laufs, Ulrich
Dinov, Borislav
author_sort Ueberham, Laura
collection PubMed
description Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research.
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spelling pubmed-101115132023-04-19 Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis Ueberham, Laura Hagendorff, Andreas Klingel, Karin Paetsch, Ingo Jahnke, Cosima Kluge, Theresa Ebbinghaus, Hans Hindricks, Gerhard Laufs, Ulrich Dinov, Borislav J Am Heart Assoc Mini‐review Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research. John Wiley and Sons Inc. 2023-03-09 /pmc/articles/PMC10111513/ /pubmed/36892055 http://dx.doi.org/10.1161/JAHA.122.027971 Text en © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Mini‐review
Ueberham, Laura
Hagendorff, Andreas
Klingel, Karin
Paetsch, Ingo
Jahnke, Cosima
Kluge, Theresa
Ebbinghaus, Hans
Hindricks, Gerhard
Laufs, Ulrich
Dinov, Borislav
Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
title Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
title_full Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
title_fullStr Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
title_full_unstemmed Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
title_short Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
title_sort pathophysiological gaps, diagnostic challenges, and uncertainties in cardiac sarcoidosis
topic Mini‐review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111513/
https://www.ncbi.nlm.nih.gov/pubmed/36892055
http://dx.doi.org/10.1161/JAHA.122.027971
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