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Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis
BACKGROUND: Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) null genotypes have been considered risk factors for many cancers. Numerous studies have been conducted to evaluate the association of null genotype of GSTM1 and GSTT1 with increased susceptibility to oral canc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112102/ https://www.ncbi.nlm.nih.gov/pubmed/37082039 http://dx.doi.org/10.4103/jomfp.jomfp_435_21 |
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author | Kumar, K Vinod Goturi, Anitha Nagaraj, M Goud, E V Soma Sekhar |
author_facet | Kumar, K Vinod Goturi, Anitha Nagaraj, M Goud, E V Soma Sekhar |
author_sort | Kumar, K Vinod |
collection | PubMed |
description | BACKGROUND: Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) null genotypes have been considered risk factors for many cancers. Numerous studies have been conducted to evaluate the association of null genotype of GSTM1 and GSTT1 with increased susceptibility to oral cancers, and these have produced inconsistent and inconclusive results. In the present study, the possible association of oral cancer(OC) with GSTM1 and GSTT1 null genotypes was explored by a meta analysis. MATERIALS AND METHODS: A meta-analysis was conducted on published original studies retrieved from the literature using a bibliographic search from two electronic databases: MEDLINE (National library of medicine, USA) and EMBASE. The pooled odds ratio and presence of publication bias in those studies were evaluated. RESULTS: A total of 49 studies concerning oral cancer (OC) were identified for GSTM1 null genotype. Similarly, 36 studies were identified for GSTT1 null genotype. The pooled OR was 1.551(95% confidence interval [CI]: 1.355–1.774) for the GSTM1 null genotype, while for GSTT1 null genotype, the pooled OR was 1.377 (95% CI: 1.155–1.642). No evidence of publication bias was detected among the included studies. CONCLUSION: The results suggest that the Glutathione S-transferase M1 and Glutathione S-transferase T1 null genotypes significantly enhances the risk of developing oral cancer by a substantial percentage. |
format | Online Article Text |
id | pubmed-10112102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-101121022023-04-19 Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis Kumar, K Vinod Goturi, Anitha Nagaraj, M Goud, E V Soma Sekhar J Oral Maxillofac Pathol Original Article BACKGROUND: Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) null genotypes have been considered risk factors for many cancers. Numerous studies have been conducted to evaluate the association of null genotype of GSTM1 and GSTT1 with increased susceptibility to oral cancers, and these have produced inconsistent and inconclusive results. In the present study, the possible association of oral cancer(OC) with GSTM1 and GSTT1 null genotypes was explored by a meta analysis. MATERIALS AND METHODS: A meta-analysis was conducted on published original studies retrieved from the literature using a bibliographic search from two electronic databases: MEDLINE (National library of medicine, USA) and EMBASE. The pooled odds ratio and presence of publication bias in those studies were evaluated. RESULTS: A total of 49 studies concerning oral cancer (OC) were identified for GSTM1 null genotype. Similarly, 36 studies were identified for GSTT1 null genotype. The pooled OR was 1.551(95% confidence interval [CI]: 1.355–1.774) for the GSTM1 null genotype, while for GSTT1 null genotype, the pooled OR was 1.377 (95% CI: 1.155–1.642). No evidence of publication bias was detected among the included studies. CONCLUSION: The results suggest that the Glutathione S-transferase M1 and Glutathione S-transferase T1 null genotypes significantly enhances the risk of developing oral cancer by a substantial percentage. Wolters Kluwer - Medknow 2022 2022-12-22 /pmc/articles/PMC10112102/ /pubmed/37082039 http://dx.doi.org/10.4103/jomfp.jomfp_435_21 Text en Copyright: © 2022 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kumar, K Vinod Goturi, Anitha Nagaraj, M Goud, E V Soma Sekhar Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis |
title | Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis |
title_full | Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis |
title_fullStr | Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis |
title_full_unstemmed | Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis |
title_short | Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis |
title_sort | null genotypes of glutathione s-transferase m1 and t1 and risk of oral cancer: a meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112102/ https://www.ncbi.nlm.nih.gov/pubmed/37082039 http://dx.doi.org/10.4103/jomfp.jomfp_435_21 |
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