Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei

We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla(KPC-2) and mcr-9.1, and genes iutAiucABCD and iroBCDEN encoding the virulence...

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Detalles Bibliográficos
Autores principales: Huang, Yonglu, Wu, Yuchen, Cai, Chang, Zhang, Rong, Chen, Gongxiang, Dong, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112160/
https://www.ncbi.nlm.nih.gov/pubmed/36920213
http://dx.doi.org/10.1128/aac.01737-22
Descripción
Sumario:We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla(KPC-2) and mcr-9.1, and genes iutAiucABCD and iroBCDEN encoding the virulence factor, siderophores. Comparative genomics of C210017 and the 178 ST133 E. hormaechei strains in the database suggested they all belonged to serotype O3 and most strains (77.5%) carried the IncHI2 superplasmids associated with the resistance, virulence, and adaptation of the host strain.

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