Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei

We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla(KPC-2) and mcr-9.1, and genes iutAiucABCD and iroBCDEN encoding the virulence...

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Autores principales: Huang, Yonglu, Wu, Yuchen, Cai, Chang, Zhang, Rong, Chen, Gongxiang, Dong, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112160/
https://www.ncbi.nlm.nih.gov/pubmed/36920213
http://dx.doi.org/10.1128/aac.01737-22
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author Huang, Yonglu
Wu, Yuchen
Cai, Chang
Zhang, Rong
Chen, Gongxiang
Dong, Ning
author_facet Huang, Yonglu
Wu, Yuchen
Cai, Chang
Zhang, Rong
Chen, Gongxiang
Dong, Ning
author_sort Huang, Yonglu
collection PubMed
description We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla(KPC-2) and mcr-9.1, and genes iutAiucABCD and iroBCDEN encoding the virulence factor, siderophores. Comparative genomics of C210017 and the 178 ST133 E. hormaechei strains in the database suggested they all belonged to serotype O3 and most strains (77.5%) carried the IncHI2 superplasmids associated with the resistance, virulence, and adaptation of the host strain.
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spelling pubmed-101121602023-04-19 Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei Huang, Yonglu Wu, Yuchen Cai, Chang Zhang, Rong Chen, Gongxiang Dong, Ning Antimicrob Agents Chemother Mechanisms of Resistance We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla(KPC-2) and mcr-9.1, and genes iutAiucABCD and iroBCDEN encoding the virulence factor, siderophores. Comparative genomics of C210017 and the 178 ST133 E. hormaechei strains in the database suggested they all belonged to serotype O3 and most strains (77.5%) carried the IncHI2 superplasmids associated with the resistance, virulence, and adaptation of the host strain. American Society for Microbiology 2023-03-15 /pmc/articles/PMC10112160/ /pubmed/36920213 http://dx.doi.org/10.1128/aac.01737-22 Text en Copyright © 2023 Huang et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Huang, Yonglu
Wu, Yuchen
Cai, Chang
Zhang, Rong
Chen, Gongxiang
Dong, Ning
Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
title Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
title_full Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
title_fullStr Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
title_full_unstemmed Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
title_short Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
title_sort phenotypic and genomic characterization of st133 siderophore-encoding extensively drug-resistant enterobacter hormaechei
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112160/
https://www.ncbi.nlm.nih.gov/pubmed/36920213
http://dx.doi.org/10.1128/aac.01737-22
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