The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae

The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increa...

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Detalles Bibliográficos
Autores principales: D’Angelo, Francesca, Rocha, Eduardo P. C., Rendueles, Olaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112221/
https://www.ncbi.nlm.nih.gov/pubmed/36912665
http://dx.doi.org/10.1128/aac.00127-23
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author D’Angelo, Francesca
Rocha, Eduardo P. C.
Rendueles, Olaya
author_facet D’Angelo, Francesca
Rocha, Eduardo P. C.
Rendueles, Olaya
author_sort D’Angelo, Francesca
collection PubMed
description The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured using the MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for its inactivation.
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spelling pubmed-101122212023-04-19 The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae D’Angelo, Francesca Rocha, Eduardo P. C. Rendueles, Olaya Antimicrob Agents Chemother Mechanisms of Resistance The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured using the MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for its inactivation. American Society for Microbiology 2023-03-13 /pmc/articles/PMC10112221/ /pubmed/36912665 http://dx.doi.org/10.1128/aac.00127-23 Text en Copyright © 2023 D’Angelo et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
D’Angelo, Francesca
Rocha, Eduardo P. C.
Rendueles, Olaya
The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae
title The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae
title_full The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae
title_fullStr The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae
title_full_unstemmed The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae
title_short The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae
title_sort capsule increases susceptibility to last-resort polymyxins, but not to other antibiotics, in klebsiella pneumoniae
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112221/
https://www.ncbi.nlm.nih.gov/pubmed/36912665
http://dx.doi.org/10.1128/aac.00127-23
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