Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950

Specific targets for cancer treatment are highly desirable, but still remain to be discovered. While previous reports suggested that CAPRIN-1 localizes in the cytoplasm, here we now show that part of this molecule is strongly expressed on the cell membrane surface in most solid cancers, but not norm...

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Detalles Bibliográficos
Autores principales: Okano, Fumiyoshi, Saito, Takanori, Minamida, Yoshitaka, Kobayashi, Shinichi, Ido, Takayoshi, Miyauchi, Yasushi, Wasai, Ukei, Akazawa, Daisuke, Kume, Masahiko, Ishibashi, Masaki, Jiang, Ke, Aicher, Alexandra, Heeschen, Christopher, Yonehara, Tetsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112292/
https://www.ncbi.nlm.nih.gov/pubmed/37082579
http://dx.doi.org/10.1158/2767-9764.CRC-22-0310

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