SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics

RATIONALE: Genetic studies suggest that SOX17 (SRY-related HMG-box 17) deficiency increases pulmonary arterial hypertension (PAH) risk. OBJECTIVES: On the basis of pathological roles of estrogen and HIF2α (hypoxia-inducible factor 2α) signaling in pulmonary artery endothelial cells (PAECs), we hypot...

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Detalles Bibliográficos
Autores principales: Sangam, Shreya, Sun, Xutong, Schwantes-An, Tae-Hwi, Yegambaram, Manivannan, Lu, Qing, Shi, Yinan, Cook, Todd, Fisher, Amanda, Frump, Andrea L., Coleman, Anna, Sun, Yanan, Liang, Shuxin, Crawford, Howard, Lutz, Katie A., Maun, Avinash D., Pauciulo, Michael W., Karnes, Jason H., Chaudhary, Ketul R., Stewart, Duncan J., Langlais, Paul R., Jain, Mohit, Alotaibi, Mona, Lahm, Tim, Jin, Yan, Gu, Haiwei, Tang, Haiyang, Nichols, William C., Black, Stephen M., Desai, Ankit A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112457/
https://www.ncbi.nlm.nih.gov/pubmed/36913491
http://dx.doi.org/10.1164/rccm.202203-0450OC

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