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Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency

OBJECTIVES: There is still controversy about the effect of vitamin D supplementation on osteoarthritis (OA). The purpose of this study was to investigate the effects of vitamin D supplementation with Hyaluronic acid (HA) injection on OA. METHODS: We investigated serum vitamin D levels and oxidative...

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Autores principales: Shen, Jianlin, Lin, Xiaoning, Lin, Yujin, Xiao, Jiecheng, Wu, Changfu, Zheng, Feng, Wu, Xianwei, Lin, Haibin, Chen, Guoli, Liu, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112517/
https://www.ncbi.nlm.nih.gov/pubmed/37081922
http://dx.doi.org/10.3389/fnut.2023.1026722
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author Shen, Jianlin
Lin, Xiaoning
Lin, Yujin
Xiao, Jiecheng
Wu, Changfu
Zheng, Feng
Wu, Xianwei
Lin, Haibin
Chen, Guoli
Liu, Huan
author_facet Shen, Jianlin
Lin, Xiaoning
Lin, Yujin
Xiao, Jiecheng
Wu, Changfu
Zheng, Feng
Wu, Xianwei
Lin, Haibin
Chen, Guoli
Liu, Huan
author_sort Shen, Jianlin
collection PubMed
description OBJECTIVES: There is still controversy about the effect of vitamin D supplementation on osteoarthritis (OA). The purpose of this study was to investigate the effects of vitamin D supplementation with Hyaluronic acid (HA) injection on OA. METHODS: We investigated serum vitamin D levels and oxidative stress (OS) in synovial fluid from patients with OA who underwent total knee arthroplasty (grade IV, n = 24) and HA injection (grade II and III, n = 40). The effects of HA injection with or without oral vitamin D supplementation on synovial fluid OS and knee pain and function were then further investigated. Finally, patients underwent HA injection were divided into two groups according to vitamin D levels (vitamin D < or > 30 ng/ml), and the efficacy of the two groups were compared. RESULTS: The results showed that the levels of glutathione peroxidase (GSH-PX) (P < 0.05) in the synovial fluid were lower in patients with stage IV OA than that in patients with stage II-III OA, while the levels of malondialdehyde (MDA) (P < 0.05) and lactate dehydrogenase (LDH) (P < 0.01) were significantly higher. Moreover, we found that age, BMI and vitamin D levels were significantly associated with the levels of oxidants and/or antioxidants in synovial fluid, and that vitamin D was significantly negatively correlated with BMI (R = −0.3527, p = 0.0043). Supplementation of HA injections with vitamin D significantly reduced the OS status in synovial fluid, attenuated knee pain and improved knee function in OA patients with vitamin D insufficiency. CONCLUSION: We conclude that maintenance of vitamin D sufficiency may be beneficial for the treatment of OA by improving OS in synovial fluid.
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spelling pubmed-101125172023-04-19 Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency Shen, Jianlin Lin, Xiaoning Lin, Yujin Xiao, Jiecheng Wu, Changfu Zheng, Feng Wu, Xianwei Lin, Haibin Chen, Guoli Liu, Huan Front Nutr Nutrition OBJECTIVES: There is still controversy about the effect of vitamin D supplementation on osteoarthritis (OA). The purpose of this study was to investigate the effects of vitamin D supplementation with Hyaluronic acid (HA) injection on OA. METHODS: We investigated serum vitamin D levels and oxidative stress (OS) in synovial fluid from patients with OA who underwent total knee arthroplasty (grade IV, n = 24) and HA injection (grade II and III, n = 40). The effects of HA injection with or without oral vitamin D supplementation on synovial fluid OS and knee pain and function were then further investigated. Finally, patients underwent HA injection were divided into two groups according to vitamin D levels (vitamin D < or > 30 ng/ml), and the efficacy of the two groups were compared. RESULTS: The results showed that the levels of glutathione peroxidase (GSH-PX) (P < 0.05) in the synovial fluid were lower in patients with stage IV OA than that in patients with stage II-III OA, while the levels of malondialdehyde (MDA) (P < 0.05) and lactate dehydrogenase (LDH) (P < 0.01) were significantly higher. Moreover, we found that age, BMI and vitamin D levels were significantly associated with the levels of oxidants and/or antioxidants in synovial fluid, and that vitamin D was significantly negatively correlated with BMI (R = −0.3527, p = 0.0043). Supplementation of HA injections with vitamin D significantly reduced the OS status in synovial fluid, attenuated knee pain and improved knee function in OA patients with vitamin D insufficiency. CONCLUSION: We conclude that maintenance of vitamin D sufficiency may be beneficial for the treatment of OA by improving OS in synovial fluid. Frontiers Media S.A. 2023-04-04 /pmc/articles/PMC10112517/ /pubmed/37081922 http://dx.doi.org/10.3389/fnut.2023.1026722 Text en Copyright © 2023 Shen, Lin, Lin, Xiao, Wu, Zheng, Wu, Lin, Chen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Shen, Jianlin
Lin, Xiaoning
Lin, Yujin
Xiao, Jiecheng
Wu, Changfu
Zheng, Feng
Wu, Xianwei
Lin, Haibin
Chen, Guoli
Liu, Huan
Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
title Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
title_full Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
title_fullStr Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
title_full_unstemmed Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
title_short Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency
title_sort supplementation of hyaluronic acid injections with vitamin d improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin d insufficiency
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112517/
https://www.ncbi.nlm.nih.gov/pubmed/37081922
http://dx.doi.org/10.3389/fnut.2023.1026722
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