Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson’s disease cohort

BACKGROUND: Large-scale Parkinson’s disease (PD) genome-wide association studies (GWAS) have, until recently, only been conducted on subjects with European-ancestry. Consequently, polygenic risk scores (PRS) constructed using PD GWAS data are likely to be less predictive when applied to non-European...

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Detalles Bibliográficos
Autores principales: Loesch, Douglas P., Horimoto, Andrea R.V.R., Sarihan, Elif Irem, Inca-Martinez, Miguel, Mason, Emily, Cornejo-Olivas, Mario, Torres, Luis, Mazzetti, Pilar, Cosentino, Carlos, Sarapura-Castro, Elison, Rivera-Valdivia, Andrea, Medina, Angel C., Dieguez, Elena, Raggio, Victor, Lescano, Andres, Tumas, Vitor, Borges, Vanderci, Ferraz, Henrique B., Rieder, Carlos R., Schumacher-Schuh, Artur, Santos-Lobato, Bruno L., Velez-Pardo, Carlos, Jimenez-Del-Rio, Marlene, Lopera, Francisco, Moreno, Sonia, Chana-Cuevas, Pedro, Fernandez, William, Arboleda, Gonzalo, Arboleda, Humberto, Arboleda-Bustos, Carlos E., Yearout, Dora, Zabetian, Cyrus P., Thornton, Timothy A., Mata, Ignacio F., O’Connor, Timothy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112543/
https://www.ncbi.nlm.nih.gov/pubmed/35917738
http://dx.doi.org/10.1016/j.parkreldis.2022.06.010

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