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Analysis of cognitive function and its related factors after treatment in Meniere’s disease

A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere’s disease (MD), a common clinical vestibular disorder, is usually accompanied by hearing loss and emotional stress, both of which may mediate the relationship between vestib...

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Autores principales: Zhong, Jiake, Li, Xin, Xu, Jia, Chen, Wenjing, Gao, Juanjuan, Lu, Xingxing, Liang, Sichao, Guo, Zhenping, Lu, Manlin, Li, Yunshuo, Yi, Haijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112666/
https://www.ncbi.nlm.nih.gov/pubmed/37081934
http://dx.doi.org/10.3389/fnins.2023.1137734
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author Zhong, Jiake
Li, Xin
Xu, Jia
Chen, Wenjing
Gao, Juanjuan
Lu, Xingxing
Liang, Sichao
Guo, Zhenping
Lu, Manlin
Li, Yunshuo
Yi, Haijin
author_facet Zhong, Jiake
Li, Xin
Xu, Jia
Chen, Wenjing
Gao, Juanjuan
Lu, Xingxing
Liang, Sichao
Guo, Zhenping
Lu, Manlin
Li, Yunshuo
Yi, Haijin
author_sort Zhong, Jiake
collection PubMed
description A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere’s disease (MD), a common clinical vestibular disorder, is usually accompanied by hearing loss and emotional stress, both of which may mediate the relationship between vestibule dysfunction and cognition. It is currently unknown whether the cognitive decline in MD patients could improve through treatment and how it relates to multiple clinical characteristics, particularly the severity of vertigo. Therefore, in the present study, the MD patients were followed up for 3, 6, and 12 months after treatment, and the cognitive functions, vertigo symptoms, and related physical, functional, and emotional effects of the patients were assessed using the Montreal Cognitive Assessment (MoCA) and Dizziness Handicap Inventory (DHI), aiming to explore the change in cognition before and after therapy and the correlation with various clinical features. It was found that cognitive decline in MD patients compared to healthy controls before therapy. Importantly, this cognitive impairment could improve after effective therapy, which was related to the severity of vertigo, especially in functional and physical impacts. Our results support the view that vestibular dysfunction is a potentially modifiable risk factor for cognitive decline.
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spelling pubmed-101126662023-04-19 Analysis of cognitive function and its related factors after treatment in Meniere’s disease Zhong, Jiake Li, Xin Xu, Jia Chen, Wenjing Gao, Juanjuan Lu, Xingxing Liang, Sichao Guo, Zhenping Lu, Manlin Li, Yunshuo Yi, Haijin Front Neurosci Neuroscience A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere’s disease (MD), a common clinical vestibular disorder, is usually accompanied by hearing loss and emotional stress, both of which may mediate the relationship between vestibule dysfunction and cognition. It is currently unknown whether the cognitive decline in MD patients could improve through treatment and how it relates to multiple clinical characteristics, particularly the severity of vertigo. Therefore, in the present study, the MD patients were followed up for 3, 6, and 12 months after treatment, and the cognitive functions, vertigo symptoms, and related physical, functional, and emotional effects of the patients were assessed using the Montreal Cognitive Assessment (MoCA) and Dizziness Handicap Inventory (DHI), aiming to explore the change in cognition before and after therapy and the correlation with various clinical features. It was found that cognitive decline in MD patients compared to healthy controls before therapy. Importantly, this cognitive impairment could improve after effective therapy, which was related to the severity of vertigo, especially in functional and physical impacts. Our results support the view that vestibular dysfunction is a potentially modifiable risk factor for cognitive decline. Frontiers Media S.A. 2023-04-04 /pmc/articles/PMC10112666/ /pubmed/37081934 http://dx.doi.org/10.3389/fnins.2023.1137734 Text en Copyright © 2023 Zhong, Li, Xu, Chen, Gao, Lu, Liang, Guo, Lu, Li and Yi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhong, Jiake
Li, Xin
Xu, Jia
Chen, Wenjing
Gao, Juanjuan
Lu, Xingxing
Liang, Sichao
Guo, Zhenping
Lu, Manlin
Li, Yunshuo
Yi, Haijin
Analysis of cognitive function and its related factors after treatment in Meniere’s disease
title Analysis of cognitive function and its related factors after treatment in Meniere’s disease
title_full Analysis of cognitive function and its related factors after treatment in Meniere’s disease
title_fullStr Analysis of cognitive function and its related factors after treatment in Meniere’s disease
title_full_unstemmed Analysis of cognitive function and its related factors after treatment in Meniere’s disease
title_short Analysis of cognitive function and its related factors after treatment in Meniere’s disease
title_sort analysis of cognitive function and its related factors after treatment in meniere’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112666/
https://www.ncbi.nlm.nih.gov/pubmed/37081934
http://dx.doi.org/10.3389/fnins.2023.1137734
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