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Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research

Salmonella is an important zoonotic bacterial species and hazardous for the health of human beings and livestock globally. Depending on the host, Salmonella can cause diseases ranging from gastroenteritis to life-threatening systemic infection. In this review, we discuss the effector proteins used b...

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Autores principales: Zhou, Guodong, Zhao, Yuying, Ma, Qifeng, Li, Quan, Wang, Shifeng, Shi, Huoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112668/
https://www.ncbi.nlm.nih.gov/pubmed/37081875
http://dx.doi.org/10.3389/fimmu.2023.1152017
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author Zhou, Guodong
Zhao, Yuying
Ma, Qifeng
Li, Quan
Wang, Shifeng
Shi, Huoying
author_facet Zhou, Guodong
Zhao, Yuying
Ma, Qifeng
Li, Quan
Wang, Shifeng
Shi, Huoying
author_sort Zhou, Guodong
collection PubMed
description Salmonella is an important zoonotic bacterial species and hazardous for the health of human beings and livestock globally. Depending on the host, Salmonella can cause diseases ranging from gastroenteritis to life-threatening systemic infection. In this review, we discuss the effector proteins used by Salmonella to evade or manipulate four different levels of host immune defenses: commensal flora, intestinal epithelial-mucosal barrier, innate and adaptive immunity. At present, Salmonella has evolved a variety of strategies against host defense mechanisms, among which various effector proteins delivered by the secretory systems play a key role. During its passage through the digestive system, Salmonella has to face the intact intestinal epithelial barrier as well as competition with commensal flora. After invasion of host cells, Salmonella manipulates inflammatory pathways, ubiquitination and autophagy processes with the help of effector proteins. Finally, Salmonella evades the adaptive immune system by interfering the migration of dendritic cells and interacting with T and B lymphocytes. In conclusion, Salmonella can manipulate multiple aspects of host defense to promote its replication in the host.
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spelling pubmed-101126682023-04-19 Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research Zhou, Guodong Zhao, Yuying Ma, Qifeng Li, Quan Wang, Shifeng Shi, Huoying Front Immunol Immunology Salmonella is an important zoonotic bacterial species and hazardous for the health of human beings and livestock globally. Depending on the host, Salmonella can cause diseases ranging from gastroenteritis to life-threatening systemic infection. In this review, we discuss the effector proteins used by Salmonella to evade or manipulate four different levels of host immune defenses: commensal flora, intestinal epithelial-mucosal barrier, innate and adaptive immunity. At present, Salmonella has evolved a variety of strategies against host defense mechanisms, among which various effector proteins delivered by the secretory systems play a key role. During its passage through the digestive system, Salmonella has to face the intact intestinal epithelial barrier as well as competition with commensal flora. After invasion of host cells, Salmonella manipulates inflammatory pathways, ubiquitination and autophagy processes with the help of effector proteins. Finally, Salmonella evades the adaptive immune system by interfering the migration of dendritic cells and interacting with T and B lymphocytes. In conclusion, Salmonella can manipulate multiple aspects of host defense to promote its replication in the host. Frontiers Media S.A. 2023-04-04 /pmc/articles/PMC10112668/ /pubmed/37081875 http://dx.doi.org/10.3389/fimmu.2023.1152017 Text en Copyright © 2023 Zhou, Zhao, Ma, Li, Wang and Shi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhou, Guodong
Zhao, Yuying
Ma, Qifeng
Li, Quan
Wang, Shifeng
Shi, Huoying
Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research
title Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research
title_full Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research
title_fullStr Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research
title_full_unstemmed Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research
title_short Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research
title_sort manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of salmonella and its application in vaccine research
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112668/
https://www.ncbi.nlm.nih.gov/pubmed/37081875
http://dx.doi.org/10.3389/fimmu.2023.1152017
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