The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left–right asymmetry in the gut by promoting receptor endocytosis

Many organs of Drosophila show stereotypical left–right (LR) asymmetry; however, the underlying mechanisms remain elusive. Here, we have identified an evolutionarily conserved ubiquitin-binding protein, AWP1/Doctor No (Drn), as a factor required for LR asymmetry in the embryonic anterior gut. We fou...

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Detalles Bibliográficos
Autores principales: Lai, Yi-Ting, Sasamura, Takeshi, Kuroda, Junpei, Maeda, Reo, Nakamura, Mitsutoshi, Hatori, Ryo, Ishibashi, Tomoki, Taniguchi, Kiichiro, Ooike, Masashi, Taguchi, Tomohiro, Nakazawa, Naotaka, Hozumi, Shunya, Okumura, Takashi, Aigaki, Toshiro, Inaki, Mikiko, Matsuno, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112927/
https://www.ncbi.nlm.nih.gov/pubmed/36861793
http://dx.doi.org/10.1242/dev.201224

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