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A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)

Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging...

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Autores principales: Kirkovski, Melissa, Donaldson, Peter H., Do, Michael, Speranza, Bridgette E., Albein-Urios, Natalia, Oberman, Lindsay M., Enticott, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113132/
https://www.ncbi.nlm.nih.gov/pubmed/37072625
http://dx.doi.org/10.1007/s00429-023-02634-x
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author Kirkovski, Melissa
Donaldson, Peter H.
Do, Michael
Speranza, Bridgette E.
Albein-Urios, Natalia
Oberman, Lindsay M.
Enticott, Peter G.
author_facet Kirkovski, Melissa
Donaldson, Peter H.
Do, Michael
Speranza, Bridgette E.
Albein-Urios, Natalia
Oberman, Lindsay M.
Enticott, Peter G.
author_sort Kirkovski, Melissa
collection PubMed
description Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post-TBS in healthy human adults. Fifty studies that applied either continuous—or intermittent—(c/i) TBS, and adopted a pretest–posttest or sham-controlled design, were included. For resting-state outcomes following stimulation applied to motor, temporal, parietal, occipital, or cerebellar regions, functional connectivity generally decreased in response to cTBS and increased in response to iTBS, though there were some exceptions to this pattern of response. These findings are mostly consistent with the assumed long-term depression (LTD)/long-term potentiation (LTP)-like plasticity effects of cTBS and iTBS, respectively. Task-related outcomes following TBS were more variable. TBS applied to the prefrontal cortex, irrespective of task or state, also produced more variable responses, with no consistent patterns emerging. Individual participant and methodological factors are likely to contribute to the variability in responses to TBS. Future studies assessing the effects of TBS via fMRI must account for factors known to affect the TBS outcomes, both at the level of individual participants and of research methodology.
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spelling pubmed-101131322023-04-20 A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI) Kirkovski, Melissa Donaldson, Peter H. Do, Michael Speranza, Bridgette E. Albein-Urios, Natalia Oberman, Lindsay M. Enticott, Peter G. Brain Struct Funct Review Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post-TBS in healthy human adults. Fifty studies that applied either continuous—or intermittent—(c/i) TBS, and adopted a pretest–posttest or sham-controlled design, were included. For resting-state outcomes following stimulation applied to motor, temporal, parietal, occipital, or cerebellar regions, functional connectivity generally decreased in response to cTBS and increased in response to iTBS, though there were some exceptions to this pattern of response. These findings are mostly consistent with the assumed long-term depression (LTD)/long-term potentiation (LTP)-like plasticity effects of cTBS and iTBS, respectively. Task-related outcomes following TBS were more variable. TBS applied to the prefrontal cortex, irrespective of task or state, also produced more variable responses, with no consistent patterns emerging. Individual participant and methodological factors are likely to contribute to the variability in responses to TBS. Future studies assessing the effects of TBS via fMRI must account for factors known to affect the TBS outcomes, both at the level of individual participants and of research methodology. Springer Berlin Heidelberg 2023-04-19 2023 /pmc/articles/PMC10113132/ /pubmed/37072625 http://dx.doi.org/10.1007/s00429-023-02634-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kirkovski, Melissa
Donaldson, Peter H.
Do, Michael
Speranza, Bridgette E.
Albein-Urios, Natalia
Oberman, Lindsay M.
Enticott, Peter G.
A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)
title A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)
title_full A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)
title_fullStr A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)
title_full_unstemmed A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)
title_short A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)
title_sort systematic review of the neurobiological effects of theta-burst stimulation (tbs) as measured using functional magnetic resonance imaging (fmri)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113132/
https://www.ncbi.nlm.nih.gov/pubmed/37072625
http://dx.doi.org/10.1007/s00429-023-02634-x
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