Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres

RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How ultrahigh-affinity binding and dynamic turnover are achieved simultaneously is n...

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Detalles Bibliográficos
Autores principales: Spegg, Vincent, Panagopoulos, Andreas, Stout, Merula, Krishnan, Aswini, Reginato, Giordano, Imhof, Ralph, Roschitzki, Bernd, Cejka, Petr, Altmeyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113159/
https://www.ncbi.nlm.nih.gov/pubmed/36894693
http://dx.doi.org/10.1038/s41594-023-00932-w

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