Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree

The transcription factor p63 shares a high sequence identity with the tumour suppressor p53 which manifests itself in high structural similarity and preference for DNA sequences. Mutations in the DNA binding domain (DBD) of p53 have been studied in great detail, enabling a general mechanism-based cl...

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Detalles Bibliográficos
Autores principales: Osterburg, Christian, Ferniani, Marco, Antonini, Dario, Frombach, Ann-Sophie, D’Auria, Ludovica, Osterburg, Susanne, Lotz, Rebecca, Löhr, Frank, Kehrloesser, Sebastian, Zhou, Huiqing, Missero, Caterina, Dötsch, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113246/
https://www.ncbi.nlm.nih.gov/pubmed/37072394
http://dx.doi.org/10.1038/s41419-023-05796-y

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