In vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants

Alpha-protein kinase 1 (ALPK1) is a pathogen recognition receptor that detects ADP-heptose (ADPH), a lipopolysaccharide biosynthesis intermediate, recently described as a pathogen-associated molecular pattern in Gram-negative bacteria. ADPH binding to ALPK1 activates its kinase domain and triggers T...

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Detalles Bibliográficos
Autores principales: García-Weber, Diego, Dangeard, Anne-Sophie, Teixeira, Veronica, Hauke, Martina, Carreaux, Alexis, Josenhans, Christine, Arrieumerlou, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113258/
https://www.ncbi.nlm.nih.gov/pubmed/37072480
http://dx.doi.org/10.1038/s41598-023-33459-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113258/
https://www.ncbi.nlm.nih.gov/pubmed/37072480
http://dx.doi.org/10.1038/s41598-023-33459-7

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