Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion

An inherited gain-of-function variant (E756del) in the mechanosensitive cationic channel PIEZO1 was shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) infection by Plasmodium falciparum is prevented by the pharmacological ac...

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Detalles Bibliográficos
Autores principales: Lohia, Rakhee, Allegrini, Benoit, Berry, Laurence, Guizouarn, Hélène, Cerdan, Rachel, Abkarian, Manouk, Douguet, Dominique, Honoré, Eric, Wengelnik, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113305/
https://www.ncbi.nlm.nih.gov/pubmed/37071200
http://dx.doi.org/10.1007/s00018-023-04773-0

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