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Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder
BACKGROUND: Major depressive disorder (MDD) is a disabling and severe psychiatric disorder with a high rate of prevalence, and adolescence is one of the most probable periods for the first onset. The neurobiological mechanism underlying the adolescent MDD remains unexplored. METHODS: In this study,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113492/ https://www.ncbi.nlm.nih.gov/pubmed/37091700 http://dx.doi.org/10.3389/fpsyt.2023.1157587 |
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author | Zhang, Xiaoliu Cao, Jun Huang, Qian Hong, Su Dai, Linqi Chen, Xiaorong Chen, Jianmei Ai, Ming Gan, Yao He, Jinglan Kuang, Li |
author_facet | Zhang, Xiaoliu Cao, Jun Huang, Qian Hong, Su Dai, Linqi Chen, Xiaorong Chen, Jianmei Ai, Ming Gan, Yao He, Jinglan Kuang, Li |
author_sort | Zhang, Xiaoliu |
collection | PubMed |
description | BACKGROUND: Major depressive disorder (MDD) is a disabling and severe psychiatric disorder with a high rate of prevalence, and adolescence is one of the most probable periods for the first onset. The neurobiological mechanism underlying the adolescent MDD remains unexplored. METHODS: In this study, we examined the cortical and subcortical alterations of neuroanatomical structures and spontaneous functional activation in 50 unmedicated adolescents with MDD vs. 39 healthy controls through the combined structural and resting-state functional magnetic resonance imaging. RESULTS: Significantly altered regional gray matter volume was found at broader frontal-temporal-parietal and subcortical brain areas involved with various forms of information processing in adolescent MDD. Specifically, the increased GM volume at the left paracentral lobule and right supplementary motor cortex was significantly correlated with depression severity in adolescent MDD. Furthermore, lower cortical thickness at brain areas responsible for visual and auditory processing as well as motor movements was found in adolescent MDD. The lower cortical thickness at the superior premotor subdivision was positively correlated with the course of the disease. Moreover, higher spontaneous neuronal activity was found at the anterior cingulum and medial prefrontal cortex, and this hyperactivity was also negatively correlated with the course of the disease. It potentially reflected the rumination, impaired concentration, and physiological arousal in adolescent MDD. CONCLUSION: The abnormal structural and functional findings at cortico-subcortical areas implied the dysfunctional cognitive control and emotional regulations in adolescent depression. The findings might help elaborate the underlying neural mechanisms of MDD in adolescents. |
format | Online Article Text |
id | pubmed-10113492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101134922023-04-20 Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder Zhang, Xiaoliu Cao, Jun Huang, Qian Hong, Su Dai, Linqi Chen, Xiaorong Chen, Jianmei Ai, Ming Gan, Yao He, Jinglan Kuang, Li Front Psychiatry Psychiatry BACKGROUND: Major depressive disorder (MDD) is a disabling and severe psychiatric disorder with a high rate of prevalence, and adolescence is one of the most probable periods for the first onset. The neurobiological mechanism underlying the adolescent MDD remains unexplored. METHODS: In this study, we examined the cortical and subcortical alterations of neuroanatomical structures and spontaneous functional activation in 50 unmedicated adolescents with MDD vs. 39 healthy controls through the combined structural and resting-state functional magnetic resonance imaging. RESULTS: Significantly altered regional gray matter volume was found at broader frontal-temporal-parietal and subcortical brain areas involved with various forms of information processing in adolescent MDD. Specifically, the increased GM volume at the left paracentral lobule and right supplementary motor cortex was significantly correlated with depression severity in adolescent MDD. Furthermore, lower cortical thickness at brain areas responsible for visual and auditory processing as well as motor movements was found in adolescent MDD. The lower cortical thickness at the superior premotor subdivision was positively correlated with the course of the disease. Moreover, higher spontaneous neuronal activity was found at the anterior cingulum and medial prefrontal cortex, and this hyperactivity was also negatively correlated with the course of the disease. It potentially reflected the rumination, impaired concentration, and physiological arousal in adolescent MDD. CONCLUSION: The abnormal structural and functional findings at cortico-subcortical areas implied the dysfunctional cognitive control and emotional regulations in adolescent depression. The findings might help elaborate the underlying neural mechanisms of MDD in adolescents. Frontiers Media S.A. 2023-04-05 /pmc/articles/PMC10113492/ /pubmed/37091700 http://dx.doi.org/10.3389/fpsyt.2023.1157587 Text en Copyright © 2023 Zhang, Cao, Huang, Hong, Dai, Chen, Chen, Ai, Gan, He and Kuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zhang, Xiaoliu Cao, Jun Huang, Qian Hong, Su Dai, Linqi Chen, Xiaorong Chen, Jianmei Ai, Ming Gan, Yao He, Jinglan Kuang, Li Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
title | Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
title_full | Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
title_fullStr | Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
title_full_unstemmed | Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
title_short | Severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
title_sort | severity related neuroanatomical and spontaneous functional activity alteration in adolescents with major depressive disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113492/ https://www.ncbi.nlm.nih.gov/pubmed/37091700 http://dx.doi.org/10.3389/fpsyt.2023.1157587 |
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