Potential adverse actions of prenatal exposure of acetaminophen to offspring

Acetaminophen (APAP) is a widely used as analgesic and antipyretic drug. APAP is also added as an active ingredient in various medications to relieve pain and reduce fever. APAP has been widely used in pregnant women in the past decades because it is considered a relatively safe drug with recommende...

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Autores principales: Wu, Ka, Lu, Wensheng, Yan, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113502/
https://www.ncbi.nlm.nih.gov/pubmed/37089952
http://dx.doi.org/10.3389/fphar.2023.1094435
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author Wu, Ka
Lu, Wensheng
Yan, Xin
author_facet Wu, Ka
Lu, Wensheng
Yan, Xin
author_sort Wu, Ka
collection PubMed
description Acetaminophen (APAP) is a widely used as analgesic and antipyretic drug. APAP is also added as an active ingredient in various medications to relieve pain and reduce fever. APAP has been widely used in pregnant women in the past decades because it is considered a relatively safe drug with recommended dose in different countries. However, an increasing number of epidemiological and experimental studies have shown that APAP exposure during pregnancy may increase the risk of inducing reproductive and neurobehavior dysfunctions, hepatotoxicity in offspring. This review aims to assess the potential effects of prenatal APAP exposure on offspring growth and development.
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spelling pubmed-101135022023-04-20 Potential adverse actions of prenatal exposure of acetaminophen to offspring Wu, Ka Lu, Wensheng Yan, Xin Front Pharmacol Pharmacology Acetaminophen (APAP) is a widely used as analgesic and antipyretic drug. APAP is also added as an active ingredient in various medications to relieve pain and reduce fever. APAP has been widely used in pregnant women in the past decades because it is considered a relatively safe drug with recommended dose in different countries. However, an increasing number of epidemiological and experimental studies have shown that APAP exposure during pregnancy may increase the risk of inducing reproductive and neurobehavior dysfunctions, hepatotoxicity in offspring. This review aims to assess the potential effects of prenatal APAP exposure on offspring growth and development. Frontiers Media S.A. 2023-04-05 /pmc/articles/PMC10113502/ /pubmed/37089952 http://dx.doi.org/10.3389/fphar.2023.1094435 Text en Copyright © 2023 Wu, Lu and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wu, Ka
Lu, Wensheng
Yan, Xin
Potential adverse actions of prenatal exposure of acetaminophen to offspring
title Potential adverse actions of prenatal exposure of acetaminophen to offspring
title_full Potential adverse actions of prenatal exposure of acetaminophen to offspring
title_fullStr Potential adverse actions of prenatal exposure of acetaminophen to offspring
title_full_unstemmed Potential adverse actions of prenatal exposure of acetaminophen to offspring
title_short Potential adverse actions of prenatal exposure of acetaminophen to offspring
title_sort potential adverse actions of prenatal exposure of acetaminophen to offspring
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113502/
https://www.ncbi.nlm.nih.gov/pubmed/37089952
http://dx.doi.org/10.3389/fphar.2023.1094435
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