Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis

BACKGROUND: The present systematic review aimed to investigate the drug susceptibility patterns of Iranian clinical Candida albicans isolates to antifungal drugs (azoles, polyenes, and echinocandins). METHODS: Six electronic databases including “PubMed,” “Scopus,” “Web of Science,” “IranDoc”, “SID”,...

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Autores principales: Kermani, Firoozeh, Taghizadeh-Armaki, Mojtaba, Hosseini, Seyed Abdollah, Amirrajab, Nasrin, Javidnia, Javad, Fami Zaghrami, Mahmoud, Shokohi, Tahereh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2023
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Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113589/
https://www.ncbi.nlm.nih.gov/pubmed/37089147
http://dx.doi.org/10.18502/ijph.v52i2.11874
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author Kermani, Firoozeh
Taghizadeh-Armaki, Mojtaba
Hosseini, Seyed Abdollah
Amirrajab, Nasrin
Javidnia, Javad
Fami Zaghrami, Mahmoud
Shokohi, Tahereh
author_facet Kermani, Firoozeh
Taghizadeh-Armaki, Mojtaba
Hosseini, Seyed Abdollah
Amirrajab, Nasrin
Javidnia, Javad
Fami Zaghrami, Mahmoud
Shokohi, Tahereh
author_sort Kermani, Firoozeh
collection PubMed
description BACKGROUND: The present systematic review aimed to investigate the drug susceptibility patterns of Iranian clinical Candida albicans isolates to antifungal drugs (azoles, polyenes, and echinocandins). METHODS: Six electronic databases including “PubMed,” “Scopus,” “Web of Science,” “IranDoc”, “SID”, and “Magiran” were searched from May 2000 to June 2021. The susceptibility of 6322 C. albicans strains from 19967 patients against 14 antifungal drugs was evaluated according to CLSI method. RESULTS: The pooled prevalence of antifungal resistance ranged from 0% to 26%. The lowest resistance levels among azoles were observed in luliconazole with a frequency of 0% and voriconazole of 3.94%. CONCLUSION: Due to the emergence of multi-drug resistant C. albicans, rational drug prescription based on the anti-fungal stewardship strategy and therapeutic drug monitoring is warranted.
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spelling pubmed-101135892023-04-20 Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis Kermani, Firoozeh Taghizadeh-Armaki, Mojtaba Hosseini, Seyed Abdollah Amirrajab, Nasrin Javidnia, Javad Fami Zaghrami, Mahmoud Shokohi, Tahereh Iran J Public Health Review Article BACKGROUND: The present systematic review aimed to investigate the drug susceptibility patterns of Iranian clinical Candida albicans isolates to antifungal drugs (azoles, polyenes, and echinocandins). METHODS: Six electronic databases including “PubMed,” “Scopus,” “Web of Science,” “IranDoc”, “SID”, and “Magiran” were searched from May 2000 to June 2021. The susceptibility of 6322 C. albicans strains from 19967 patients against 14 antifungal drugs was evaluated according to CLSI method. RESULTS: The pooled prevalence of antifungal resistance ranged from 0% to 26%. The lowest resistance levels among azoles were observed in luliconazole with a frequency of 0% and voriconazole of 3.94%. CONCLUSION: Due to the emergence of multi-drug resistant C. albicans, rational drug prescription based on the anti-fungal stewardship strategy and therapeutic drug monitoring is warranted. Tehran University of Medical Sciences 2023-02 /pmc/articles/PMC10113589/ /pubmed/37089147 http://dx.doi.org/10.18502/ijph.v52i2.11874 Text en Copyright © 2023 Kermani et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Review Article
Kermani, Firoozeh
Taghizadeh-Armaki, Mojtaba
Hosseini, Seyed Abdollah
Amirrajab, Nasrin
Javidnia, Javad
Fami Zaghrami, Mahmoud
Shokohi, Tahereh
Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis
title Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis
title_full Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis
title_fullStr Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis
title_full_unstemmed Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis
title_short Antifungal Resistance of Clinical Candida albicans Isolates in Iran: A Systematic Review and Meta-Analysis
title_sort antifungal resistance of clinical candida albicans isolates in iran: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113589/
https://www.ncbi.nlm.nih.gov/pubmed/37089147
http://dx.doi.org/10.18502/ijph.v52i2.11874
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