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Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein

BACKGROUND: Colorectal cancer is the third most common malignant tumor in the world and substantial death cases are reported each year. We aimed to explore the molecular mechanism underlying colorectal cancer tumor-igenesis and progression. METHODS: The expression levels of Forkhead box A2 (FOXA2) i...

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Autores principales: Zeng, Xiangyue, Yang, Xinhui, Parhatsayim, Shayim, Abudoukelimu, Abulajiang, Shu, Yin, Zhao, Zeliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113591/
https://www.ncbi.nlm.nih.gov/pubmed/37089159
http://dx.doi.org/10.18502/ijph.v52i2.11883
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author Zeng, Xiangyue
Yang, Xinhui
Parhatsayim, Shayim
Abudoukelimu, Abulajiang
Shu, Yin
Zhao, Zeliang
author_facet Zeng, Xiangyue
Yang, Xinhui
Parhatsayim, Shayim
Abudoukelimu, Abulajiang
Shu, Yin
Zhao, Zeliang
author_sort Zeng, Xiangyue
collection PubMed
description BACKGROUND: Colorectal cancer is the third most common malignant tumor in the world and substantial death cases are reported each year. We aimed to explore the molecular mechanism underlying colorectal cancer tumor-igenesis and progression. METHODS: The expression levels of Forkhead box A2 (FOXA2) in colorectal cancer tissues were first analyzed using Gene Expression Profiling Interactive Analysis (GEPIA). More multiple in vitro experiments established the role of FOXA2 in colorectal cancer progression. The potential downstream target of FOXA2 was identified by Western blot analysis. RESULTS: FOXA2 expression level was significantly up-modulated in colorectal cancer specimens and cells (P<0.05). Silencing FOXA2 remarkably inhibited colorectal cancer cells growth, invasion and migration. BCL2-associated X (BAX) protein was identified as a potential downstream protein of FOXA2. CONCLUSION: Our findings demonstrated the essential role of FOXA2 in colorectal cancer progression and identified BAX protein as its potential target.
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spelling pubmed-101135912023-04-20 Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein Zeng, Xiangyue Yang, Xinhui Parhatsayim, Shayim Abudoukelimu, Abulajiang Shu, Yin Zhao, Zeliang Iran J Public Health Original Article BACKGROUND: Colorectal cancer is the third most common malignant tumor in the world and substantial death cases are reported each year. We aimed to explore the molecular mechanism underlying colorectal cancer tumor-igenesis and progression. METHODS: The expression levels of Forkhead box A2 (FOXA2) in colorectal cancer tissues were first analyzed using Gene Expression Profiling Interactive Analysis (GEPIA). More multiple in vitro experiments established the role of FOXA2 in colorectal cancer progression. The potential downstream target of FOXA2 was identified by Western blot analysis. RESULTS: FOXA2 expression level was significantly up-modulated in colorectal cancer specimens and cells (P<0.05). Silencing FOXA2 remarkably inhibited colorectal cancer cells growth, invasion and migration. BCL2-associated X (BAX) protein was identified as a potential downstream protein of FOXA2. CONCLUSION: Our findings demonstrated the essential role of FOXA2 in colorectal cancer progression and identified BAX protein as its potential target. Tehran University of Medical Sciences 2023-02 /pmc/articles/PMC10113591/ /pubmed/37089159 http://dx.doi.org/10.18502/ijph.v52i2.11883 Text en Copyright © 2023 Zeng et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Zeng, Xiangyue
Yang, Xinhui
Parhatsayim, Shayim
Abudoukelimu, Abulajiang
Shu, Yin
Zhao, Zeliang
Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
title Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
title_full Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
title_fullStr Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
title_full_unstemmed Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
title_short Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
title_sort forkhead box a2 promotes colorectal cancer progression and targets bcl2-associated x (bax) protein
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113591/
https://www.ncbi.nlm.nih.gov/pubmed/37089159
http://dx.doi.org/10.18502/ijph.v52i2.11883
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