Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters

This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protei...

Descripción completa

Detalles Bibliográficos
Autores principales: Kovalenko, A.O., Ryabchevskaya, E.M., Evtushenko, E.A., Kondakova, O.A., Ivanov, P.A., Arkhipenko, M.V., Nikitin, N.A., Karpova, O.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113597/
https://www.ncbi.nlm.nih.gov/pubmed/37095758
http://dx.doi.org/10.1016/j.dib.2023.109158
Descripción
Sumario:This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protein fragments and a structurally modified plant virus – spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters’ lungs are provided.

Ejemplares similares