Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters

This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protei...

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Autores principales: Kovalenko, A.O., Ryabchevskaya, E.M., Evtushenko, E.A., Kondakova, O.A., Ivanov, P.A., Arkhipenko, M.V., Nikitin, N.A., Karpova, O.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113597/
https://www.ncbi.nlm.nih.gov/pubmed/37095758
http://dx.doi.org/10.1016/j.dib.2023.109158
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author Kovalenko, A.O.
Ryabchevskaya, E.M.
Evtushenko, E.A.
Kondakova, O.A.
Ivanov, P.A.
Arkhipenko, M.V.
Nikitin, N.A.
Karpova, O.V.
author_facet Kovalenko, A.O.
Ryabchevskaya, E.M.
Evtushenko, E.A.
Kondakova, O.A.
Ivanov, P.A.
Arkhipenko, M.V.
Nikitin, N.A.
Karpova, O.V.
author_sort Kovalenko, A.O.
collection PubMed
description This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protein fragments and a structurally modified plant virus – spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters’ lungs are provided.
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spelling pubmed-101135972023-04-19 Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters Kovalenko, A.O. Ryabchevskaya, E.M. Evtushenko, E.A. Kondakova, O.A. Ivanov, P.A. Arkhipenko, M.V. Nikitin, N.A. Karpova, O.V. Data Brief Data Article This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protein fragments and a structurally modified plant virus – spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters’ lungs are provided. Elsevier 2023-04-19 /pmc/articles/PMC10113597/ /pubmed/37095758 http://dx.doi.org/10.1016/j.dib.2023.109158 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Kovalenko, A.O.
Ryabchevskaya, E.M.
Evtushenko, E.A.
Kondakova, O.A.
Ivanov, P.A.
Arkhipenko, M.V.
Nikitin, N.A.
Karpova, O.V.
Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
title Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
title_full Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
title_fullStr Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
title_full_unstemmed Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
title_short Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters
title_sort dataset on safety and protective efficacy studies of covid-19 vaccine candidates based on structurally modified plant virus in female hamsters
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113597/
https://www.ncbi.nlm.nih.gov/pubmed/37095758
http://dx.doi.org/10.1016/j.dib.2023.109158
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