Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication

Human Angiotensin-Converting Enzyme 2 (hACE2) is the major receptor enabling host cell invasion by SARS-CoV-2 via interaction with Spike. The murine ACE2 does not interact efficiently with SARS-CoV-2 Spike and therefore the laboratory mouse strains are not permissive to SARS-CoV-2 replication. Here,...

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Detalles Bibliográficos
Autores principales: Le Chevalier, Fabien, Authié, Pierre, Chardenoux, Sébastien, Bourgine, Maryline, Vesin, Benjamin, Cussigh, Delphine, Sassier, Yohann, Fert, Ingrid, Noirat, Amandine, Nemirov, Kirill, Anna, François, Bérard, Marion, Guinet, Françoise, Hardy, David, Charneau, Pierre, Lemonnier, François, Langa-Vives, Francina, Majlessi, Laleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Masson SAS on behalf of Institut Pasteur. 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113602/
https://www.ncbi.nlm.nih.gov/pubmed/37080384
http://dx.doi.org/10.1016/j.micinf.2023.105142

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