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Biomarkers in autoimmune diseases of the central nervous system
The autoimmune diseases of the central nervous system (CNS) represent individual heterogeneity with different disease entities. Although clinical and imaging features make it possible to characterize larger patient cohorts, they may not provide sufficient evidence to detect disease activity and resp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113662/ https://www.ncbi.nlm.nih.gov/pubmed/37090723 http://dx.doi.org/10.3389/fimmu.2023.1111719 |
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author | Zhang, Fenghe Gao, Xue Liu, Jia Zhang, Chao |
author_facet | Zhang, Fenghe Gao, Xue Liu, Jia Zhang, Chao |
author_sort | Zhang, Fenghe |
collection | PubMed |
description | The autoimmune diseases of the central nervous system (CNS) represent individual heterogeneity with different disease entities. Although clinical and imaging features make it possible to characterize larger patient cohorts, they may not provide sufficient evidence to detect disease activity and response to disease modifying drugs. Biomarkers are becoming a powerful tool due to their objectivity and easy access. Biomarkers may indicate various aspects of biological processes in healthy and/or pathological states, or as a response to drug therapy. According to the clinical features described, biomarkers are usually classified into predictive, diagnostic, monitoring and safety biomarkers. Some nerve injury markers, humoral markers, cytokines and immune cells in serum or cerebrospinal fluid have potential roles in disease severity and prognosis in autoimmune diseases occurring in the CNS, which provides a promising approach for clinicians to early intervention and prevention of future disability. Therefore, this review mainly summarizes the potential biomarkers indicated in autoimmune disorders of the CNS. |
format | Online Article Text |
id | pubmed-10113662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101136622023-04-20 Biomarkers in autoimmune diseases of the central nervous system Zhang, Fenghe Gao, Xue Liu, Jia Zhang, Chao Front Immunol Immunology The autoimmune diseases of the central nervous system (CNS) represent individual heterogeneity with different disease entities. Although clinical and imaging features make it possible to characterize larger patient cohorts, they may not provide sufficient evidence to detect disease activity and response to disease modifying drugs. Biomarkers are becoming a powerful tool due to their objectivity and easy access. Biomarkers may indicate various aspects of biological processes in healthy and/or pathological states, or as a response to drug therapy. According to the clinical features described, biomarkers are usually classified into predictive, diagnostic, monitoring and safety biomarkers. Some nerve injury markers, humoral markers, cytokines and immune cells in serum or cerebrospinal fluid have potential roles in disease severity and prognosis in autoimmune diseases occurring in the CNS, which provides a promising approach for clinicians to early intervention and prevention of future disability. Therefore, this review mainly summarizes the potential biomarkers indicated in autoimmune disorders of the CNS. Frontiers Media S.A. 2023-04-05 /pmc/articles/PMC10113662/ /pubmed/37090723 http://dx.doi.org/10.3389/fimmu.2023.1111719 Text en Copyright © 2023 Zhang, Gao, Liu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhang, Fenghe Gao, Xue Liu, Jia Zhang, Chao Biomarkers in autoimmune diseases of the central nervous system |
title | Biomarkers in autoimmune diseases of the central nervous system |
title_full | Biomarkers in autoimmune diseases of the central nervous system |
title_fullStr | Biomarkers in autoimmune diseases of the central nervous system |
title_full_unstemmed | Biomarkers in autoimmune diseases of the central nervous system |
title_short | Biomarkers in autoimmune diseases of the central nervous system |
title_sort | biomarkers in autoimmune diseases of the central nervous system |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113662/ https://www.ncbi.nlm.nih.gov/pubmed/37090723 http://dx.doi.org/10.3389/fimmu.2023.1111719 |
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