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Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis

OBJECTIVES: The leading cause of mortality in patients with rheumatoid arthritis is atherosclerotic cardiovascular disease (CVD). We have shown that murine arthritis impairs atherosclerotic lesion regression, because of cellular cholesterol efflux defects in haematopoietic stem and progenitor cells...

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Detalles Bibliográficos
Autores principales: Dragoljevic, Dragana, Lee, Man Kit Sam, Pernes, Gerard, Morgan, Pooranee K, Louis, Cynthia, Shihata, Waled, Huynh, Kevin, Kochetkova, Arina A, Bell, Patrick W, Mellett, Natalie A, Meikle, Peter J, Lancaster, Graeme I, Kraakman, Michael J, Nagareddy, Prabhakara R, Hanaoka, Beatriz Y, Wicks, Ian P, Murphy, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113696/
https://www.ncbi.nlm.nih.gov/pubmed/37091327
http://dx.doi.org/10.1002/cti2.1446