Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity

Stromal cells promote extensive fibrosis in pancreatic ductal adenocarcinoma (PDAC), which is associated with poor prognosis and therapeutic resistance. We report here for the first time that loss of the RNA-binding protein human antigen R (HuR, ELAVL1) in PDAC cells leads to reprogramming of the tu...

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Detalles Bibliográficos
Autores principales: McCarthy, Grace A, Di Niro, Roberto, Finan, Jennifer M, Jain, Aditi, Guo, Yifei, Wyatt, Cory R, Guimaraes, Alexander R, Waugh, Trent A, Keith, Dove, Morgan, Terry K, Sears, Rosalie C, Brody, Jonathan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Cancer-specific RNAs and RNA Processing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113877/
https://www.ncbi.nlm.nih.gov/pubmed/37089813
http://dx.doi.org/10.1093/narcan/zcad016

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