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Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs

GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid cells. Serial transplantation of Gfi1 deficient HSCs repopulated whole hematopoietic system but in a competitive setting involving wild-type...

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Detalles Bibliográficos
Autores principales:	Xie, Xiaoqing, Patnana, Pradeep Kumar, Frank, Daria, Schütte, Judith, Al-Matary, Yahya, Künstner, Axel, Busch, Hauke, Ahmed, Helal, Liu, Longlong, Engel, Daniel R., Dührsen, Ulrich, Rosenbauer, Frank, Von Bubnoff, Nikolas, Lenz, Georg, Khandanpour, Cyrus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113925/ https://www.ncbi.nlm.nih.gov/pubmed/37091981 http://dx.doi.org/10.3389/fcell.2023.866847

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