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Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation

Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significa...

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Autores principales: Zhang, Qing, Ul Ain, Qurrat, Schulz, Christian, Pircher, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114025/
https://www.ncbi.nlm.nih.gov/pubmed/37090695
http://dx.doi.org/10.3389/fimmu.2023.1151926
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author Zhang, Qing
Ul Ain, Qurrat
Schulz, Christian
Pircher, Joachim
author_facet Zhang, Qing
Ul Ain, Qurrat
Schulz, Christian
Pircher, Joachim
author_sort Zhang, Qing
collection PubMed
description Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significantly advanced and inflammation has become a crucial element. Neutrophils as most frequent immune cells in the blood and their released mediators play a key role herein. Neutrophil-derived cathelicidin next to its strong antimicrobial properties has also shown to modulates thrombosis and thus presents a potential therapeutic target. In this article we review direct and indirect (immune- and endothelial cell-mediated) effects of cathelicidin on platelets and the coagulation system. Further we discuss its implications for large vessel thrombosis and consecutive thromboinflammation as well as immunothrombosis in sepsis and COVID-19 and give an outlook for potential therapeutic prospects.
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spelling pubmed-101140252023-04-20 Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation Zhang, Qing Ul Ain, Qurrat Schulz, Christian Pircher, Joachim Front Immunol Immunology Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significantly advanced and inflammation has become a crucial element. Neutrophils as most frequent immune cells in the blood and their released mediators play a key role herein. Neutrophil-derived cathelicidin next to its strong antimicrobial properties has also shown to modulates thrombosis and thus presents a potential therapeutic target. In this article we review direct and indirect (immune- and endothelial cell-mediated) effects of cathelicidin on platelets and the coagulation system. Further we discuss its implications for large vessel thrombosis and consecutive thromboinflammation as well as immunothrombosis in sepsis and COVID-19 and give an outlook for potential therapeutic prospects. Frontiers Media S.A. 2023-04-05 /pmc/articles/PMC10114025/ /pubmed/37090695 http://dx.doi.org/10.3389/fimmu.2023.1151926 Text en Copyright © 2023 Zhang, Ul Ain, Schulz and Pircher https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Qing
Ul Ain, Qurrat
Schulz, Christian
Pircher, Joachim
Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
title Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
title_full Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
title_fullStr Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
title_full_unstemmed Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
title_short Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
title_sort role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114025/
https://www.ncbi.nlm.nih.gov/pubmed/37090695
http://dx.doi.org/10.3389/fimmu.2023.1151926
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