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Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS

OBJECTIVE: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. RESULTS: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of ge...

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Autores principales: Cunningham, Deirdre A., Reid, Adam J., Hosking, Caroline, Deroost, Katrien, Tumwine-Downey, Irene, Sanders, Mandy, Langhorne, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114299/
https://www.ncbi.nlm.nih.gov/pubmed/37076932
http://dx.doi.org/10.1186/s13104-023-06322-1
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author Cunningham, Deirdre A.
Reid, Adam J.
Hosking, Caroline
Deroost, Katrien
Tumwine-Downey, Irene
Sanders, Mandy
Langhorne, Jean
author_facet Cunningham, Deirdre A.
Reid, Adam J.
Hosking, Caroline
Deroost, Katrien
Tumwine-Downey, Irene
Sanders, Mandy
Langhorne, Jean
author_sort Cunningham, Deirdre A.
collection PubMed
description OBJECTIVE: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. RESULTS: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns are similar to what has been observed in the close relative P. berghei, but here we show that gametocyte-associated pir genes are distinct from those involved in chronic blood-stage infection and highlight a male-associated pir gene which should be the focus of future studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-023-06322-1.
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spelling pubmed-101142992023-04-20 Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS Cunningham, Deirdre A. Reid, Adam J. Hosking, Caroline Deroost, Katrien Tumwine-Downey, Irene Sanders, Mandy Langhorne, Jean BMC Res Notes Research Note OBJECTIVE: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. RESULTS: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns are similar to what has been observed in the close relative P. berghei, but here we show that gametocyte-associated pir genes are distinct from those involved in chronic blood-stage infection and highlight a male-associated pir gene which should be the focus of future studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-023-06322-1. BioMed Central 2023-04-19 /pmc/articles/PMC10114299/ /pubmed/37076932 http://dx.doi.org/10.1186/s13104-023-06322-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Cunningham, Deirdre A.
Reid, Adam J.
Hosking, Caroline
Deroost, Katrien
Tumwine-Downey, Irene
Sanders, Mandy
Langhorne, Jean
Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
title Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
title_full Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
title_fullStr Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
title_full_unstemmed Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
title_short Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
title_sort identification of gametocyte-associated pir genes in the rodent malaria parasite, plasmodium chabaudi chabaudi as
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114299/
https://www.ncbi.nlm.nih.gov/pubmed/37076932
http://dx.doi.org/10.1186/s13104-023-06322-1
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