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Correlation of vitamin D levels with serum parameters in Covid-19 patients

BACKGROUND: It is well-established that vitamins have many beneficial roles and protect humans against inflammatory diseases. Vitamin D, a lipid-soluble vitamin, plays a crucial role in viral infections. Therefore, this study aimed to investigate if serum 25(OH)D levels affect morbidity, mortality,...

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Autores principales: Beheshti, Masoud, Neisi, Niloofar, Parsanahad, Mehdi, Rasti, Mojtaba, Nashibi, Roohangiz, Cheraghian, Bahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114307/
https://www.ncbi.nlm.nih.gov/pubmed/37202065
http://dx.doi.org/10.1016/j.clnesp.2023.04.012
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author Beheshti, Masoud
Neisi, Niloofar
Parsanahad, Mehdi
Rasti, Mojtaba
Nashibi, Roohangiz
Cheraghian, Bahman
author_facet Beheshti, Masoud
Neisi, Niloofar
Parsanahad, Mehdi
Rasti, Mojtaba
Nashibi, Roohangiz
Cheraghian, Bahman
author_sort Beheshti, Masoud
collection PubMed
description BACKGROUND: It is well-established that vitamins have many beneficial roles and protect humans against inflammatory diseases. Vitamin D, a lipid-soluble vitamin, plays a crucial role in viral infections. Therefore, this study aimed to investigate if serum 25(OH)D levels affect morbidity, mortality, and levels of inflammatory parameters in COVID-19 patients. METHODS: 140 COVID-19 patients participated in this study (65 outpatients and 75 inpatients). Their blood samples were collected to determine TNFα, IL-6, D-dimer, zinc, Ca(2+), and 25(OH)D levels. Patients with O(2) saturation <93% were admitted and hospitalized in the infectious disease ward (inpatient group). Patients with O(2) saturation >93% received routine treatment and were discharged (Outpatient group). RESULTS: The serum levels of 25(OH)D in the inpatient group were significantly lower than those in the outpatient group (p < 0.001). Serum TNF-α, IL-6, and D-dimer levels in the inpatient group were significantly higher than those in the outpatient group (p < 0.001). Serum TNF-α, IL-6, and D-dimer levels were inversely correlated with 25(OH)D levels. No significant differences were observed in the serum levels of zinc and Ca(2+) between the studied groups (p = 0.96, p = 0.41 respectively). Ten out of 75 patients in the inpatient group were admitted to ICU (intubated). Nine out of them lost their lives (the mortality rate in ICU-admitted patients was 90%). CONCLUSIONS: The lower mortality and severity of COVID-19 patients with higher 25(OH)D levels represented that this vitamin alleviates the severity of COVID-19.
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spelling pubmed-101143072023-04-19 Correlation of vitamin D levels with serum parameters in Covid-19 patients Beheshti, Masoud Neisi, Niloofar Parsanahad, Mehdi Rasti, Mojtaba Nashibi, Roohangiz Cheraghian, Bahman Clin Nutr ESPEN Original Article BACKGROUND: It is well-established that vitamins have many beneficial roles and protect humans against inflammatory diseases. Vitamin D, a lipid-soluble vitamin, plays a crucial role in viral infections. Therefore, this study aimed to investigate if serum 25(OH)D levels affect morbidity, mortality, and levels of inflammatory parameters in COVID-19 patients. METHODS: 140 COVID-19 patients participated in this study (65 outpatients and 75 inpatients). Their blood samples were collected to determine TNFα, IL-6, D-dimer, zinc, Ca(2+), and 25(OH)D levels. Patients with O(2) saturation <93% were admitted and hospitalized in the infectious disease ward (inpatient group). Patients with O(2) saturation >93% received routine treatment and were discharged (Outpatient group). RESULTS: The serum levels of 25(OH)D in the inpatient group were significantly lower than those in the outpatient group (p < 0.001). Serum TNF-α, IL-6, and D-dimer levels in the inpatient group were significantly higher than those in the outpatient group (p < 0.001). Serum TNF-α, IL-6, and D-dimer levels were inversely correlated with 25(OH)D levels. No significant differences were observed in the serum levels of zinc and Ca(2+) between the studied groups (p = 0.96, p = 0.41 respectively). Ten out of 75 patients in the inpatient group were admitted to ICU (intubated). Nine out of them lost their lives (the mortality rate in ICU-admitted patients was 90%). CONCLUSIONS: The lower mortality and severity of COVID-19 patients with higher 25(OH)D levels represented that this vitamin alleviates the severity of COVID-19. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. 2023-06 2023-04-19 /pmc/articles/PMC10114307/ /pubmed/37202065 http://dx.doi.org/10.1016/j.clnesp.2023.04.012 Text en © 2023 Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Beheshti, Masoud
Neisi, Niloofar
Parsanahad, Mehdi
Rasti, Mojtaba
Nashibi, Roohangiz
Cheraghian, Bahman
Correlation of vitamin D levels with serum parameters in Covid-19 patients
title Correlation of vitamin D levels with serum parameters in Covid-19 patients
title_full Correlation of vitamin D levels with serum parameters in Covid-19 patients
title_fullStr Correlation of vitamin D levels with serum parameters in Covid-19 patients
title_full_unstemmed Correlation of vitamin D levels with serum parameters in Covid-19 patients
title_short Correlation of vitamin D levels with serum parameters in Covid-19 patients
title_sort correlation of vitamin d levels with serum parameters in covid-19 patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114307/
https://www.ncbi.nlm.nih.gov/pubmed/37202065
http://dx.doi.org/10.1016/j.clnesp.2023.04.012
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