L-Arginine in diabetes: clinical and preclinical evidence

L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has benefic...

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Autores principales: Forzano, Imma, Avvisato, Roberta, Varzideh, Fahimeh, Jankauskas, Stanislovas S., Cioppa, Angelo, Mone, Pasquale, Salemme, Luigi, Kansakar, Urna, Tesorio, Tullio, Trimarco, Valentina, Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114382/
https://www.ncbi.nlm.nih.gov/pubmed/37072850
http://dx.doi.org/10.1186/s12933-023-01827-2
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author Forzano, Imma
Avvisato, Roberta
Varzideh, Fahimeh
Jankauskas, Stanislovas S.
Cioppa, Angelo
Mone, Pasquale
Salemme, Luigi
Kansakar, Urna
Tesorio, Tullio
Trimarco, Valentina
Santulli, Gaetano
author_facet Forzano, Imma
Avvisato, Roberta
Varzideh, Fahimeh
Jankauskas, Stanislovas S.
Cioppa, Angelo
Mone, Pasquale
Salemme, Luigi
Kansakar, Urna
Tesorio, Tullio
Trimarco, Valentina
Santulli, Gaetano
author_sort Forzano, Imma
collection PubMed
description L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic.
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spelling pubmed-101143822023-04-20 L-Arginine in diabetes: clinical and preclinical evidence Forzano, Imma Avvisato, Roberta Varzideh, Fahimeh Jankauskas, Stanislovas S. Cioppa, Angelo Mone, Pasquale Salemme, Luigi Kansakar, Urna Tesorio, Tullio Trimarco, Valentina Santulli, Gaetano Cardiovasc Diabetol Review L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in animal models and in human subjects. In the literature there are several lines of evidence indicating that L-Arg has beneficial effects in diabetes and numerous studies advocate its administration to attenuate glucose intolerance in diabetic patients. Here we present a comprehensive overview of the main studies exploring the effects of L-Arg in diabetes, including preclinical and clinical reports on this topic. BioMed Central 2023-04-18 /pmc/articles/PMC10114382/ /pubmed/37072850 http://dx.doi.org/10.1186/s12933-023-01827-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Forzano, Imma
Avvisato, Roberta
Varzideh, Fahimeh
Jankauskas, Stanislovas S.
Cioppa, Angelo
Mone, Pasquale
Salemme, Luigi
Kansakar, Urna
Tesorio, Tullio
Trimarco, Valentina
Santulli, Gaetano
L-Arginine in diabetes: clinical and preclinical evidence
title L-Arginine in diabetes: clinical and preclinical evidence
title_full L-Arginine in diabetes: clinical and preclinical evidence
title_fullStr L-Arginine in diabetes: clinical and preclinical evidence
title_full_unstemmed L-Arginine in diabetes: clinical and preclinical evidence
title_short L-Arginine in diabetes: clinical and preclinical evidence
title_sort l-arginine in diabetes: clinical and preclinical evidence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114382/
https://www.ncbi.nlm.nih.gov/pubmed/37072850
http://dx.doi.org/10.1186/s12933-023-01827-2
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