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Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China
BACKGROUND: Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors asso...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114443/ https://www.ncbi.nlm.nih.gov/pubmed/37072804 http://dx.doi.org/10.1186/s13034-023-00601-2 |
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author | Zhou, Yesheng Tang, Kailing Lu, Hongyan Chen, Hongli Xie, Haomin Li, Zeyu Huang, Jinghua Fang, Ningye Chen, Siya Wang, Hong He, Qin Chen, Huanhuan Liu, Xiu Lan, Guanghua Zhu, Qiuying Chen, Yi Zhang, Xiangjun Ruan, Yuhua Liang, Shujia |
author_facet | Zhou, Yesheng Tang, Kailing Lu, Hongyan Chen, Hongli Xie, Haomin Li, Zeyu Huang, Jinghua Fang, Ningye Chen, Siya Wang, Hong He, Qin Chen, Huanhuan Liu, Xiu Lan, Guanghua Zhu, Qiuying Chen, Yi Zhang, Xiangjun Ruan, Yuhua Liang, Shujia |
author_sort | Zhou, Yesheng |
collection | PubMed |
description | BACKGROUND: Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes. METHODS: This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants’ HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure. RESULTS: The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure. CONCLUSIONS: Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes. |
format | Online Article Text |
id | pubmed-10114443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101144432023-04-20 Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China Zhou, Yesheng Tang, Kailing Lu, Hongyan Chen, Hongli Xie, Haomin Li, Zeyu Huang, Jinghua Fang, Ningye Chen, Siya Wang, Hong He, Qin Chen, Huanhuan Liu, Xiu Lan, Guanghua Zhu, Qiuying Chen, Yi Zhang, Xiangjun Ruan, Yuhua Liang, Shujia Child Adolesc Psychiatry Ment Health Research BACKGROUND: Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes. METHODS: This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants’ HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure. RESULTS: The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure. CONCLUSIONS: Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes. BioMed Central 2023-04-18 /pmc/articles/PMC10114443/ /pubmed/37072804 http://dx.doi.org/10.1186/s13034-023-00601-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhou, Yesheng Tang, Kailing Lu, Hongyan Chen, Hongli Xie, Haomin Li, Zeyu Huang, Jinghua Fang, Ningye Chen, Siya Wang, Hong He, Qin Chen, Huanhuan Liu, Xiu Lan, Guanghua Zhu, Qiuying Chen, Yi Zhang, Xiangjun Ruan, Yuhua Liang, Shujia Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
title | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
title_full | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
title_fullStr | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
title_full_unstemmed | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
title_short | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
title_sort | behavioral and emotional difficulties and hiv treatment outcomes among hiv-infected children in rural southwestern china |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114443/ https://www.ncbi.nlm.nih.gov/pubmed/37072804 http://dx.doi.org/10.1186/s13034-023-00601-2 |
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