Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form

BACKGROUND: The development of drugs for Alzheimer’s disease (AD), which is related to the misfolding and aggregation of amyloid-β (Aβ), is high in demand due to the growing number of AD patients. In this study, we screened 22 kinds of 5-mer synthetic peptides derived from the Box A region of Tob1 p...

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Detalles Bibliográficos
Autores principales: Nakamura, Rina, Konishi, Motomi, Higashi, Youichirou, Saito, Motoaki, Akizawa, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114458/
https://www.ncbi.nlm.nih.gov/pubmed/37076912
http://dx.doi.org/10.1186/s13195-023-01229-2

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