Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis

A 70-year-old male with a known case of beta-thalassemia trait and was on yearly follow-up was found to have a hemoglobin of 14.8 g/dL, hematocrit of 47.7%, and RBC count of 6.0 × 10(12)/L. Total leukocyte count (TLC) was 5 × 10(9)/L and platelet count was 4 × 10(9)/L. Secondary causes of polycythem...

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Detalles Bibliográficos
Autores principales: Khan, Afaq A., Rathod, Santosh G., Geelani, Sajad A., Roshan, Reshma, Bhatt, Javid R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114569/
https://www.ncbi.nlm.nih.gov/pubmed/37091000
http://dx.doi.org/10.4103/jfmpc.jfmpc_1473_22
Descripción
Sumario:A 70-year-old male with a known case of beta-thalassemia trait and was on yearly follow-up was found to have a hemoglobin of 14.8 g/dL, hematocrit of 47.7%, and RBC count of 6.0 × 10(12)/L. Total leukocyte count (TLC) was 5 × 10(9)/L and platelet count was 4 × 10(9)/L. Secondary causes of polycythemia were ruled out (e.g., renal or cardiac disease and smoking). He did not have symptoms of hyperviscosity syndrome. The abdominal ultrasound showed no abnormalities. On further investigation, a JAK-2 (Exon 14) mutation was detected in this patient confirming the diagnosis of polycythemia vera (PV).

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