Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis

A 70-year-old male with a known case of beta-thalassemia trait and was on yearly follow-up was found to have a hemoglobin of 14.8 g/dL, hematocrit of 47.7%, and RBC count of 6.0 × 10(12)/L. Total leukocyte count (TLC) was 5 × 10(9)/L and platelet count was 4 × 10(9)/L. Secondary causes of polycythem...

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Autores principales: Khan, Afaq A., Rathod, Santosh G., Geelani, Sajad A., Roshan, Reshma, Bhatt, Javid R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114569/
https://www.ncbi.nlm.nih.gov/pubmed/37091000
http://dx.doi.org/10.4103/jfmpc.jfmpc_1473_22
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author Khan, Afaq A.
Rathod, Santosh G.
Geelani, Sajad A.
Roshan, Reshma
Bhatt, Javid R.
author_facet Khan, Afaq A.
Rathod, Santosh G.
Geelani, Sajad A.
Roshan, Reshma
Bhatt, Javid R.
author_sort Khan, Afaq A.
collection PubMed
description A 70-year-old male with a known case of beta-thalassemia trait and was on yearly follow-up was found to have a hemoglobin of 14.8 g/dL, hematocrit of 47.7%, and RBC count of 6.0 × 10(12)/L. Total leukocyte count (TLC) was 5 × 10(9)/L and platelet count was 4 × 10(9)/L. Secondary causes of polycythemia were ruled out (e.g., renal or cardiac disease and smoking). He did not have symptoms of hyperviscosity syndrome. The abdominal ultrasound showed no abnormalities. On further investigation, a JAK-2 (Exon 14) mutation was detected in this patient confirming the diagnosis of polycythemia vera (PV).
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spelling pubmed-101145692023-04-20 Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis Khan, Afaq A. Rathod, Santosh G. Geelani, Sajad A. Roshan, Reshma Bhatt, Javid R. J Family Med Prim Care Case Report A 70-year-old male with a known case of beta-thalassemia trait and was on yearly follow-up was found to have a hemoglobin of 14.8 g/dL, hematocrit of 47.7%, and RBC count of 6.0 × 10(12)/L. Total leukocyte count (TLC) was 5 × 10(9)/L and platelet count was 4 × 10(9)/L. Secondary causes of polycythemia were ruled out (e.g., renal or cardiac disease and smoking). He did not have symptoms of hyperviscosity syndrome. The abdominal ultrasound showed no abnormalities. On further investigation, a JAK-2 (Exon 14) mutation was detected in this patient confirming the diagnosis of polycythemia vera (PV). Wolters Kluwer - Medknow 2023-02 2023-02-28 /pmc/articles/PMC10114569/ /pubmed/37091000 http://dx.doi.org/10.4103/jfmpc.jfmpc_1473_22 Text en Copyright: © 2023 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Khan, Afaq A.
Rathod, Santosh G.
Geelani, Sajad A.
Roshan, Reshma
Bhatt, Javid R.
Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
title Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
title_full Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
title_fullStr Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
title_full_unstemmed Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
title_short Polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
title_sort polycythemia vera in patients of beta-thalassemia trait and stress erythropoiesis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114569/
https://www.ncbi.nlm.nih.gov/pubmed/37091000
http://dx.doi.org/10.4103/jfmpc.jfmpc_1473_22
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