Cargando…

Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks

Clinical outcomes for many childhood brain tumours remain poor, despite our increasing understanding of the underlying disease biology. Advances in molecular diagnostics have refined our ability to classify tumour types and subtypes, and efforts are underway across multiple international paediatric...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Chris, Straathof, Karin, Fouladi, Maryam, Hargrave, Darren, Prados, Michael, Resnick, Adam, Doz, Francois, Jones, David T.W., Mueller, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114612/
https://www.ncbi.nlm.nih.gov/pubmed/37091147
http://dx.doi.org/10.3389/fonc.2023.1167082
_version_ 1785028046628061184
author Jones, Chris
Straathof, Karin
Fouladi, Maryam
Hargrave, Darren
Prados, Michael
Resnick, Adam
Doz, Francois
Jones, David T.W.
Mueller, Sabine
author_facet Jones, Chris
Straathof, Karin
Fouladi, Maryam
Hargrave, Darren
Prados, Michael
Resnick, Adam
Doz, Francois
Jones, David T.W.
Mueller, Sabine
author_sort Jones, Chris
collection PubMed
description Clinical outcomes for many childhood brain tumours remain poor, despite our increasing understanding of the underlying disease biology. Advances in molecular diagnostics have refined our ability to classify tumour types and subtypes, and efforts are underway across multiple international paediatric neuro-oncology consortia to take novel biological insights in the worst prognosis entities into innovative clinical trials. Whilst for the first time we are designing such studies on the basis of disease-specific biological data, the levels of preclincial evidence in appropriate model systems on which these trials are initiated is still widely variable. We have considered these issues between CONNECT, PNOC and ITCC-Brain, and developed a framework in which we can assess novel concepts being brought forward for possible clinical translation. Whilst not intended to be proscriptive for every possible circumstance, these criteria provide a basis for self-assessment of evidence by laboratory scientists, and a platform for discussion and rational decision-making prior to moving forward clinically.
format Online
Article
Text
id pubmed-10114612
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-101146122023-04-20 Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks Jones, Chris Straathof, Karin Fouladi, Maryam Hargrave, Darren Prados, Michael Resnick, Adam Doz, Francois Jones, David T.W. Mueller, Sabine Front Oncol Oncology Clinical outcomes for many childhood brain tumours remain poor, despite our increasing understanding of the underlying disease biology. Advances in molecular diagnostics have refined our ability to classify tumour types and subtypes, and efforts are underway across multiple international paediatric neuro-oncology consortia to take novel biological insights in the worst prognosis entities into innovative clinical trials. Whilst for the first time we are designing such studies on the basis of disease-specific biological data, the levels of preclincial evidence in appropriate model systems on which these trials are initiated is still widely variable. We have considered these issues between CONNECT, PNOC and ITCC-Brain, and developed a framework in which we can assess novel concepts being brought forward for possible clinical translation. Whilst not intended to be proscriptive for every possible circumstance, these criteria provide a basis for self-assessment of evidence by laboratory scientists, and a platform for discussion and rational decision-making prior to moving forward clinically. Frontiers Media S.A. 2023-04-05 /pmc/articles/PMC10114612/ /pubmed/37091147 http://dx.doi.org/10.3389/fonc.2023.1167082 Text en Copyright © 2023 Jones, Straathof, Fouladi, Hargrave, Prados, Resnick, Doz, Jones and Mueller https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jones, Chris
Straathof, Karin
Fouladi, Maryam
Hargrave, Darren
Prados, Michael
Resnick, Adam
Doz, Francois
Jones, David T.W.
Mueller, Sabine
Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks
title Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks
title_full Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks
title_fullStr Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks
title_full_unstemmed Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks
title_short Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks
title_sort evaluating preclinical evidence for clinical translation in childhood brain tumours: guidelines from the connect, pnoc, and itcc brain networks
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114612/
https://www.ncbi.nlm.nih.gov/pubmed/37091147
http://dx.doi.org/10.3389/fonc.2023.1167082
work_keys_str_mv AT joneschris evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT straathofkarin evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT fouladimaryam evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT hargravedarren evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT pradosmichael evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT resnickadam evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT dozfrancois evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT jonesdavidtw evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks
AT muellersabine evaluatingpreclinicalevidenceforclinicaltranslationinchildhoodbraintumoursguidelinesfromtheconnectpnocanditccbrainnetworks