PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability

The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of varia...

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Detalles Bibliográficos
Autores principales: Fevga, Christina, Tesson, Christelle, Carreras Mascaro, Ana, Courtin, Thomas, van Coller, Riaan, Sakka, Salma, Ferraro, Federico, Farhat, Nouha, Bardien, Soraya, Damak, Mariem, Carr, Jonathan, Ferrien, Mélanie, Boumeester, Valerie, Hundscheid, Jasmijn, Grillenzoni, Nicola, Kessissoglou, Irini A, Kuipers, Demy J S, Quadri, Marialuisa, Corvol, Jean-Christophe, Mhiri, Chokri, Hassan, Bassem A, Breedveld, Guido J, Lesage, Suzanne, Mandemakers, Wim, Brice, Alexis, Bonifati, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115167/
https://www.ncbi.nlm.nih.gov/pubmed/36073231
http://dx.doi.org/10.1093/brain/awac326

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