Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab

PURPOSE: People with hematologic malignancies have a significantly higher risk of developing severe and protracted forms of SARS-CoV-2 infection compared to immunocompetent patients, regardless of vaccination status. RESULTS: We describe two cases of prolonged SARS-CoV-2 infection with multiple rela...

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Autores principales: Franceschini, Erica, Pellegrino, Mariachiara, Todisco, Vera, Dolci, Giovanni, Bettelli, Francesca, Meschiari, Marianna, Bedini, Andrea., Fregni-Serpini, Giulia, Grottola, Antonella, Guaraldi, Giovanni, Pecorari, Monica, Sarti, Mario, Luppi, Mario, Perno, Carlo Federico, Mussini, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115373/
https://www.ncbi.nlm.nih.gov/pubmed/37076752
http://dx.doi.org/10.1007/s15010-023-02039-2
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author Franceschini, Erica
Pellegrino, Mariachiara
Todisco, Vera
Dolci, Giovanni
Bettelli, Francesca
Meschiari, Marianna
Bedini, Andrea.
Fregni-Serpini, Giulia
Grottola, Antonella
Guaraldi, Giovanni
Pecorari, Monica
Sarti, Mario
Luppi, Mario
Perno, Carlo Federico
Mussini, Cristina
author_facet Franceschini, Erica
Pellegrino, Mariachiara
Todisco, Vera
Dolci, Giovanni
Bettelli, Francesca
Meschiari, Marianna
Bedini, Andrea.
Fregni-Serpini, Giulia
Grottola, Antonella
Guaraldi, Giovanni
Pecorari, Monica
Sarti, Mario
Luppi, Mario
Perno, Carlo Federico
Mussini, Cristina
author_sort Franceschini, Erica
collection PubMed
description PURPOSE: People with hematologic malignancies have a significantly higher risk of developing severe and protracted forms of SARS-CoV-2 infection compared to immunocompetent patients, regardless of vaccination status. RESULTS: We describe two cases of prolonged SARS-CoV-2 infection with multiple relapses of COVID-19 pneumonia in patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab. The aim is to highlight the complexity of SARS-CoV-2 infection in this fragile group of patients and the necessity of evidence-based strategies to treat them properly. CONCLUSIONS: Patients with hematological malignancies treated with bendamustine and anti-CD20 antibodies had a significant risk of prolonged and relapsing course of COVID-19. Specific preventive and therapeutic strategies should be developed for this group of patients.
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spelling pubmed-101153732023-04-20 Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab Franceschini, Erica Pellegrino, Mariachiara Todisco, Vera Dolci, Giovanni Bettelli, Francesca Meschiari, Marianna Bedini, Andrea. Fregni-Serpini, Giulia Grottola, Antonella Guaraldi, Giovanni Pecorari, Monica Sarti, Mario Luppi, Mario Perno, Carlo Federico Mussini, Cristina Infection Case Report PURPOSE: People with hematologic malignancies have a significantly higher risk of developing severe and protracted forms of SARS-CoV-2 infection compared to immunocompetent patients, regardless of vaccination status. RESULTS: We describe two cases of prolonged SARS-CoV-2 infection with multiple relapses of COVID-19 pneumonia in patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab. The aim is to highlight the complexity of SARS-CoV-2 infection in this fragile group of patients and the necessity of evidence-based strategies to treat them properly. CONCLUSIONS: Patients with hematological malignancies treated with bendamustine and anti-CD20 antibodies had a significant risk of prolonged and relapsing course of COVID-19. Specific preventive and therapeutic strategies should be developed for this group of patients. Springer Berlin Heidelberg 2023-04-19 /pmc/articles/PMC10115373/ /pubmed/37076752 http://dx.doi.org/10.1007/s15010-023-02039-2 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Report
Franceschini, Erica
Pellegrino, Mariachiara
Todisco, Vera
Dolci, Giovanni
Bettelli, Francesca
Meschiari, Marianna
Bedini, Andrea.
Fregni-Serpini, Giulia
Grottola, Antonella
Guaraldi, Giovanni
Pecorari, Monica
Sarti, Mario
Luppi, Mario
Perno, Carlo Federico
Mussini, Cristina
Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
title Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
title_full Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
title_fullStr Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
title_full_unstemmed Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
title_short Persistent SARS-CoV-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
title_sort persistent sars-cov-2 infection with multiple clinical relapses in two patients with follicular lymphoma treated with bendamustine and obinutuzumab or rituximab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115373/
https://www.ncbi.nlm.nih.gov/pubmed/37076752
http://dx.doi.org/10.1007/s15010-023-02039-2
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