Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors

The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to study and treat the central nervous system. This is due in part to the scarcity of targets known to mediate BBB crossing. To identify novel targets, we leverage a panel of adeno-associated viruses (AAVs) previ...

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Detalles Bibliográficos
Autores principales: Shay, Timothy F., Sullivan, Erin E., Ding, Xiaozhe, Chen, Xinhong, Ravindra Kumar, Sripriya, Goertsen, David, Brown, David, Crosby, Anaya, Vielmetter, Jost, Borsos, Máté, Wolfe, Damien A., Lam, Annie W., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115422/
https://www.ncbi.nlm.nih.gov/pubmed/37075114
http://dx.doi.org/10.1126/sciadv.adg6618

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