Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

DNA repair deficiencies in cancers may result in characteristic mutational patterns, as exemplified by deficiency of BRCA1/2 and efficacy prediction for PARP inhibitors. We trained and evaluated predictive models for loss-of-function (LOF) of 145 individual DNA damage response genes based on genome-...

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Detalles Bibliográficos
Autores principales: Sørensen, Simon Grund, Shrikhande, Amruta, Poulsgaard, Gustav Alexander, Christensen, Mikkel Hovden, Bertl, Johanna, Laursen, Britt Elmedal, Hoffmann, Eva R, Pedersen, Jakob Skou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115443/
https://www.ncbi.nlm.nih.gov/pubmed/36883553
http://dx.doi.org/10.7554/eLife.81224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115443/
https://www.ncbi.nlm.nih.gov/pubmed/36883553
http://dx.doi.org/10.7554/eLife.81224

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